piRNAs and PIWI -like proteins in Multiple Myeloma and their future as biomarkers and therapy targets

piARNs y proteínas similares a PIWI en el Mieloma Múltiple y su futuro como biomarcadores y blancos terapéuticos

Main Article Content

Jheremy Sebastian Reyes Barreto
Leidy Viviana Giron Jurado
Maria Paula Montoya Estrada
Iris Lorena Sánchez Moreno
Laura Tatiana Picón Moncada
Karen Luna - Orozco
Jhonathan David Guevara Ramirez
Libia Adriana Gaona Fernández
Abstract

Multiple Myeloma (MM) is the second most common hematological malignancy and one of the 19 most frequent types of cancer. Its diagnosis is a challenge due to the low rate of disease recognition, and diagnosis delays lead to the characteristic end-organ damage of the disease. New approaches to tackle that diagnosis challenge are required. Emerging evidence shows that Piwi-interacting RNAs (piRNA) promote increased methylation in MM cells. In this analysis, we delve into the latest discoveries surrounding piRNA biogenesis and functions, offering fresh perspectives on the possible uses of piRNAs in detection and diagnosis in MM. piRNA-823 increases in MM cells and positively correlates with the disease stage. Its tumorigenic actions in MM relate to intercellular communication between MM and vein endothelial cells. These findings provide the necessary information to highlight the possible role of piRNA-823 as a biomarker for MM diagnosis.

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Author Biographies (SEE)

Jheremy Sebastian Reyes Barreto, University of Los Andes

Médico, Universidad de Los Andes, Colombia.

Leidy Viviana Giron Jurado, Universidad de Santander, Colombia.

Médica, Universidad de Santander, Colombia

Maria Paula Montoya Estrada, Grupo de investigación en cáncer y medicina molecular (CAMMO)

Bacterióloga y Laboratorista Clínica, Universidad Colegio Mayor de Cundinamarca, Colombia.

Iris Lorena Sánchez Moreno, Grupo de investigación en cáncer y medicina molecular (CAMMO)

Bióloga, Universidad Pedagógica y Tecnológica de Colombia.

Laura Tatiana Picón Moncada, Universidad Colegio Mayor de Cundinamarca

Estudiante de Bacteriología y laboratorio clínico, Universidad Colegio Mayor de Cundinamarca, Colombia. Grupo de investigación en cáncer y medicina molecular (CAMMO)

Karen Luna - Orozco, Universidad Libre

Médica Internista, Magíster en Epidemiología.

Jhonathan David Guevara Ramirez, Military University Nueva Granada

Estudiante de Ingeniería biomédica, Universidad Militar Nueva Granada.

Libia Adriana Gaona Fernández, Universidad El Bosque

 Médica Familiar. Grupo de investigación en cáncer y medicina molecular (CAMMO)

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