piARNs y proteínas similares a PIWI en el Mieloma Múltiple y su futuro como biomarcadores y blancos terapéuticos
piRNAs and PIWI -like proteins in Multiple Myeloma and their future as biomarkers and therapy targets
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El Mieloma Múltiple (MM) es la segunda neoplasia hematológica más común y uno de los 19 tipos de cáncer más frecuentes. Su diagnóstico es un desafío debido a la baja tasa de reconocimiento de la enfermedad, y los retrasos en el diagnóstico conducen al daño en los órganos característico de la enfermedad. Se requieren nuevos enfoques para abordar este desafío diagnóstico. La evidencia emergente muestra que los ARN interaccionantes con Piwi (piARN) promueven un aumento de la metilación en las células de MM. En este análisis, profundizamos en los últimos descubrimientos sobre la biogénesis y funciones de los piRNA, ofreciendo nuevas perspectivas sobre los posibles usos de piARNs en la detección y diagnóstico en MM. El piARN-823 aumenta en las células de MM y se correlaciona positivamente con la etapa de la enfermedad. Sus acciones tumorigénicas en el MM están relacionadas con la comunicación intercelular entre las células de MM y las células endoteliales de las venas. Estos hallazgos proporcionan la información necesaria para resaltar el posible papel del piARN-823 como biomarcador para el diagnóstico del MM.
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