Fungoid mycosis: 10 years of experience in a specialized reference center in call-Colombia 2013- 2023

Micosis fungoide: diez años de experiencia en un centro de referencia especializado en Cali-Colombia, 2013-2023

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Tomas Andrés Acosta Pérezz
María Alejandra Obando Martínez
Rigoberto Gómez Gutiérrez
Emmanuel Orjuela
Lizeth Acosta Tascón
Abstract

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma in adults, with a growing increase in prevalence in some countries, but to date with little information from studies in the Colombian population. Objective: To describe the characteristics of a population of patients diagnosed with MF in a specialized reference center in the city of Cali, Colombia. Methods: Descriptive cross-sectional study that included patients older than 18 years of age of both sexes with a diagnosis of MF, defined by biopsy and analyzed by a complete team of pathologists, oncologists, dermatologists, treated in the outpatient and hospitalization services in the Hematoncologos , clinic based in Cali, between the years 2013 - 2023. Result: A total of 21 patients met all the criteria for entry into the study, 76% of them were women, the vast majority from the city of Cali 14 (66%), the median age was 66 years (23- 81), the average in months from the onset of symptoms to diagnosis was 23.2 months. The vast majority of patients were in early stages of the disease, the presentation in plaques was the most common (47.6%). Conclusions: In our study, a higher prevalence of the disease was observed in women, a particularly important fact because it is not the usual distribution worldwide, with an age of presentation similar to that of global studies. A very important fact in our study is that the diagnosis was established earlier compared to the global average.

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Author Biographies (SEE)

Tomas Andrés Acosta Pérezz, Universidad Libre

Residente Medicina Interna, Universidad Libre, Cali, Colombia.

María Alejandra Obando Martínez

Médica General, Universidad Icesi. Médica asistencial Dr. Rigoberto Gómez Gutiérrez.

Rigoberto Gómez Gutiérrez, Clínica Imbanaco

Médico Internista Hematooncólogo y transplante de médula ósea. Clínica Imbanaco - Hematooncólogos SA.

Emmanuel Orjuela, Universidad Libre

Residente de Medicina Interna, Universidad Libre, Cali. Grupo interinstitucional en medicina interna GIMI-1.

Lizeth Acosta Tascón, Universidad Libre

Residente de Medicina Interna, Universidad Libre, Cali. Grupo interinstitucional en medicina interna GIMI-1

References

Rueda X, Cortés C. Linfomas cutáneos. Experiencia de linfomas cutáneos entre enero de 1995 y abril de 2008 en el Instituto Nacional de Cancerología [Internet]. Rev Colomb CanCeRol. 2011;15(4):178-189. Disponible en: https://www.revistacancercol.org/index.php/cancer/article/view/428/280

Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. Clasificación de la EORTC de la OMS para los linfomas cutáneos. Sangre [Internet]. 2005;105:3768-3785. Disponible en: https://doi.org/10.1182/blood-2004-09-3502

Willemze R, Meijer CJ. Clasificación del linfoma cutáneo de células T: de Alibert a la EORTC de la OMS. J. Cutan Pathol [Internet]. 2006; 33 Suplemento 1:18-26.

Valencia, OJ, Pérez, JM, & Velásquez, MM (2010). Diagnóstico y manejo del linfoma cutáneo de células T de tipo micosis fungoides y síndrome de Sèzary. Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica [Internet]. 2022;18 (4):205-217. Disponible en: https://www.revista.asocolderma.org.co/index.php/index

Tsianakas A, Kienast AK, Hoeger PH. Infantile-onset cutaneous T-cell lymphoma. Br J Dermatol [Internet]. 2008 Dec;159(6):1338-41. Disponible en: https://doi.org/10.1111/j.1365-2133.2008.08794.x

Campbell JJ, Clark RA, Watanabe R, Kupper TS. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood [Internet]. 2010 Aug 5;116(5):767-71. Disponible en: https://doi.org/10.1182/sangre-2009-11-251926

Mirza AS, Horna P, Teer JK, Song J, Akabari R, Hussaini M, Sokol L. New Insights Into the Complex Mutational Landscape of Sézary Syndrome. Front Oncol [Internet]. 2020 Apr 21;10:514. Disponible en: https://doi.org/10.3389/fonc.2020.00514

Gameiro A, Gouveia M, Tellechea Ó, Moreno A. Childhood hypopigmented mycosis fungoides: a commonly delayed diagnosis. BMJ Case Rep [Internet]. 2014 Dec 23;2014:bcr2014208306. Disponible en: https://doi.org/10.1136/bcr-2014-208306

Valencia Ocampo OJ, Julio L, Zapata V, Correa LA, Vasco C, Correa S, Velásquez-Lopera MM. Mycosis Fungoides in Children and Adolescents: A Series of 23 Cases. Actas Dermosifiliogr (Engl Ed) [Internet]. 2020 Mar;111(2):149-156. English, Spanish. Disponible en: https://doi.org/10.1016/j.ad.2019.04.004

Nanda A, AlSaleh QA, Al-Ajmi H, Al-Sabah H, Elkashlan M, Al-Shemmari S, Demierre MF. Mycosis fungoides in Arab children and adolescents: a report of 36 patients from Kuwait. Pediatr Dermatol [Internet]. 2010 Nov-Dec;27(6):607-13. Disponible en: https://doi.org/10.1111/j.1525-1470.2010.01129.x

Criscione VD, Weinstock MA. Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002. Arch Dermatol [Internet]. 2007 Jul;143(7):854-9. Disponible en: https://doi.org/10.1001/archderm.143.7.854

Girardi M, Heald PW, Wilson LD. The pathogenesis of mycosis fungoides. N Engl J Med [Internet]. 2004 May 6;350(19):1978-88 Disponible en: https://doi.org/10.1056/NEJMra032810

Rupoli S, Barulli S, Guiducci B, Offidani M, Mozzicafreddo G, Simonacci M, Filosa G, Giacchetti A, Ricotti G, Brandozzi G, Cataldi I, Serresi S, Ceschini R, Bugatti L, Offidani A, Giangiacomi M, Brancorsini D, Leoni P. Low dose interferon-alpha2b combined with PUVA is an effective treatment of early stage mycosis fungoides: results of a multicenter study. Cutaneous-T Cell Lymphoma Multicenter Study Group. Haematologica [Internet]. 1999 Sep;84(9):809-13. Disponible en: https://pubmed.ncbi.nlm.nih.gov/10477454/ PMID: 10477454.

Smoller, B. Histopathology and genetics of cutaneous Tcell lymphoma. Hematology / Oncology Clinics of North America [Internet]. 2003;17:1277-1311 Disponible: https://doi.org/10.1016/S0889-8588(03)00115-1

Duvic M. Tratamiento actual del linfoma cutáneo de células T. Dermatology Online Journal. 2001; 7(1):3

Willemze, R., Jaffe, E. S., Burg, G., Cerroni, L., Berti, E., Swerdlow, S. H., ... & Meijer, C. J. WHO-EORTC classification for cutaneous lymphomas. Blood [Internet]. 2005;105(10):3768-3785. Disponible: https://doi.org/10.1182/blood-2004-09-3502

Lee H. Mycosis fungoides and Sézary syndrome. Blood Res [Internet]. 2023 Apr 30;58(S1):66-82. Disponible en: https://doi.org/10.5045/br.2023.2023023

Benton EC, Crichton S, Talpur R, Agar NS, Fields PA, Wedgeworth E, Mitchell TJ, Cox M, Ferreira S, Liu P, Robson A, Calonje E, Stefanato CM, Wilkins B, Scarisbrick J, Wain EM, Child F, Morris S, Duvic M, Whittaker SJ. A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome. Eur J Cancer [Internet]. 2013 Sep;49(13):2859-68. Disponible en: https://doi.org/10.1016/j.ejca.2013.04.018

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