Cutaneous leukocytoclastic vasculitis and gastric adenocarcinoma as paraneoplastic syndrome : case report.
Vasculitis leucocitoclástica cutánea en paciente con cáncer gástrico como síndrome paraneoplásico : reporte de caso.
Article Sidebar
PDF (Español (España))
FLIP
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
Main Article Content
The most common vasculitis associated with malignancy is inflammation of small vessels that most commonly presents as cutaneous leukocytoclastic vasculitis. Hematologic malignancies are more commonly associated than solid tumors and the development of cutaneous inflammation is the result of circulating immune complexes containing tumor antigens deposited along the vascular walls, leading to complement activation and vascular inflammation. About one third of leukocytoclastic vasculitis cases can precede the clinical appearance of cancer by weeks to months. We report a case of a patient with metastasic gastric cancer with progression and cutaneous leukocytoclastic vasculitis associated.
Downloads
Article Details
Loricera J, Calvo-Río V, Ortiz-Sanjuán F, González-López MA, Fernández-Llaca H, Rueda-Gotor J, et al. The spectrum of paraneoplastic cutaneous vasculitis in a defined population: incidence and clinical features. Medicine (Baltimore). 2013;92(6):331-43.
Yadav BS, Sharma SC, Kapoor RK. Paraneoplastic leukocytoclastic vasculitis in chronic lymphoid leukemia. J Cancer Res Ther. 2006;2(4):206-8.
Quack H, Erpenbeck L, Wolff HA, Sprenger T, Seitz CS, Schön MP, et al. Oxaliplatin-induced leukocytoclastic vasculitis under adjuvant chemotherapy for colorectal cancer: two cases of a rare adverse event. Case Rep Oncol. 2013;6(3):609-15.
Marques C, Sereijo M, Domingues JC, Sequeira J, Poiares-Baptista AP. Vasculite leucocitoclásica. Revisao de 51 casos. Acta Med Port. 1995;8(1):15-22. 5. Pulido-Pérez A, Avilés-Izquierdo J, Suárez-Fernández R. Vasculitis cutáneas. Actas Dermosifiliogr. 2012;103(3):179-91.
Loricera J, González-Vela C, Blanco R, Hernández JL, Armesto S, González-López MA, et al. Histopathologic differences between cutaneous vasculitis associated with severe bacterial infection and cutaneous vasculitis secondary to other causes: study of 52 patients. Clin Exp Rheumatol. 2016;34(3 Suppl 97):S93-7.
Carlson JA. The histological assessment of cutaneous vasculitis. Histopathology. 2010;56(1):3-23.
Mebazaa A, Chouk S, Azzouz H, El Euch D, Rouhou RC, Trojjet S, et al. Leukocytoclastic vasculitis and gastric adenocarcinoma. Acta Dermatovenerol Alp Pannonica Adriat. 2010;19(1):21-3.
Gogia A, Kakar A, Bhalla S, Byotra SP. Leucocytoclastic vasculitis as a presentation of adenocarcinoma rectum. J Postgrad Med. 2005;51(3):215-7.
Solans-Laqué R, Bosch-Gil JA, Pérez-Bocanegra C, SelvaO’Callaghan A, Simeón-Aznar CP, Vilardell-Tarres M. Paraneoplastic vasculitis in patients with solid tumors: report of 15 cases. J Rheumatol. 2008;35(2):294-304.
Sánchez-Guerrero J, Gutiérrez-Ureña S, Vidaller A, Reyes E, Iglesias A, Alarcón-Segovia D. Vasculitis as a paraneoplastic syndrome. Report of 11 cases and review of the literature. J Rheumatol. 1990;17(11):1458-62.
Fain O, Hamidou M, Cacoub P, Godeau B, Wechsler B, Pariès J, et al. Vasculitides associated with malignancies: analysis of sixty patients. Arthritis Rheum. 2007;57(8):1473-80.
García-Porrúa C, González-Gay MA. Cutaneous vasculitis as a paraneoplastic syndrome in adults. Arthritis Rheum. 1998;41(6):1133-5.
Agha A, Bateman H, Sterrett A, Valeriano-Marcet J. Myelodysplasia and malignancy-associated vasculitis. Curr Rheumatol Rep. 2012;14(6):526-31.
Carlson JA, Chen KR. Cutaneous vasculitis update: small vessel neutrophilic vasculitis syndromes. Am J Dermatopathol. 2006;28(6):486-506.
Kathula SK, Thomas DE, Anstadt MP, Khan AU. Paraneoplastic cutaneous leukocytoclastic vasculitis and iron deficiency anemia as the presenting features of squamous cell lung carcinoma. J Clin Oncol. 2011;29(4):83-5.
Hill SE, Phillips R, Francis N, Agnew K. Small-vessel vasculitis following treatment with combination 5-fluorouracil/folinic acid and oxaliplatin. Clin Exp Dermatol. 2009;34(1):103-5.
Al-Shamsi HO, Kee BK, Tetzlaff MT, Wolff RA. Capecitabineinduced leukocytoclastic vasculitis under neoadjuvant chemotherapy for locally advanced colorectal cancer. J Gastrointest Oncol. 2015;6(3):E40-3.
Yagi Y, Fushida S, Harada S, Kinoshita J, Makino I, Oyama K, et al. Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line. J Exp Clin Cancer Res. 2010;29:149.
Fushida S, Kaji M, Oyama K, Hirono Y, Nezuka H, Takeda T, et al. Randomized phase II trial of paclitaxel plus valproic acid vs paclitaxel alone as second-line therapy for patients with advanced gastric cancer. Onco Targets Ther. 2015;8:939-41.
Feng WH, Kenney SC. Valproic acid enhances the efficacy of chemotherapy in EBV-positive tumors by increasing lytic viral gene expression. Cancer Res. 2006;66(17):8762-9.
Hrzenjak A, Moinfar F, Kremser ML, Strohmeier B, Staber PB, Zatloukal K, et al. Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells. Mol Cancer Ther. 2006;5(9):2203- 10.
Göttlicher M, Minucci S, Zhu P, Krämer OH, Schimpf A, Giavara S, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 2001;20(24):6969-78.
