Novel molecular perspectives for the treatment of recurrent anaplastic meningiomas : a case report.

Nuevas perspectivas moleculares para el tratamiento de los meningiomas anaplásicos recurrentes : a propósito de un caso.

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José M. Behaine
Juan Armando Mejía
Nicolás Useche
Sonia Bermúdez
Andrés Felipe Cardona
Abstract

A 53-year-old woman who presented behavioral changes with attention and affection disturbances due to the diagnosis of a high grade meningioma requiring multiple surgeries followed by radiotherapy, hydroxyurea and imatinib; thereafter, the lesion progressed considering the use of octreotide plus everolimus to modulate the abnormal somatostatin receptor expression as well as the altered transcription by PIP3K/mTOR/AKT pathway. With this treatment the patient obtained a durable partial reponse.

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Author Biographies (SEE)

José M. Behaine, Universidad El Bosque ; Fundación Santa Fe de Bogotá

Instituto de Neurociencias, Universidad El Bosque (Bogotá, Colombia). Departamento de Neurocirugía, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Juan Armando Mejía, Universidad El Bosque ; Fundación Santa Fe de Bogotá

Instituto de Neurociencias, Universidad El Bosque (Bogotá, Colombia). Departamento de Neurocirugía, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Nicolás Useche, Universidad El Bosque ; Fundación Santa Fe de Bogotá

Instituto de Neurociencias, Universidad El Bosque (Bogotá, Colombia). Departamento de Imágenes Diagnósticas, Sección Neurorradiología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Sonia Bermúdez, Universidad El Bosque ; Fundación Santa Fe de Bogotá

Instituto de Neurociencias, Universidad El Bosque (Bogotá, Colombia). Departamento de Imágenes Diagnósticas, Sección Neurorradiología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Andrés Felipe Cardona, Universidad El Bosque ; Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC) ; Fundación Santa Fe de Bogotá

Instituto de Neurociencias, Universidad El Bosque (Bogotá, Colombia). Grupo de Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Fundación para la Investigación Clínica y Molecular Aplicada al Cáncer (FICMAC); Investigador asociado ONCOLGroup (Bogotá, Colombia.

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