Hematology at ASCO 2013 : building bridges to conquer cancer.
Hematología en ASCO 2013 : creando puentes para conquistar el cáncer.
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Introduction: The Meeting of the American Society of Clinical Oncology (ASCOm) gathers every year the leading world experts in malignant diseases. An ever increasing share of the ASCOm is accounted by abstracts and presentations on hematologic oncology (HO). In this article, brief commentaries are presented on key abstracts submitted to the ASCOm of 2013 on HO. Methods: Key abstracts submitted to the 2013’s ASCOm on HO were selected based on type of research (favoring clinical trials), potential clinical relevance, translational medicine (favoring proof of principle of novel targets) and media attention, with emphasis on those selected for discussion during the Highlights of the day sessions during the ASCOm. A short description and commentary is made of the selected abstracts. Results: Twenty two abstracts on HO were selected. Of note, several abstracts underscore the therapeutic potential of novel targeted agents against Bruton tyrosine kinases, PI3k delta and Bcl-2 in mature B-cell malignancies. The efficacy of lenalidomide in heavily-pretreated mantle-cell lymphoma is also presented. Newer combination chemotherapies and targeted agents against T-cell malignancies including belinostat, a novel histone de acetylase inhibitor, were presented. In multiple myeloma, post high-dose melphalan maintenance with lenalidomide appears to improve clinical outcomes. Also in multiple myeloma, several new agents appear to be safe and effective including carfilzomib and the oral MLN9708 (proteasome inhibitors), pomalidomide (a new imid) and the anti CD38, elotuzumab. Two abstracts suggest that routine follow-up imaging studies after definitive therapy of both Hodgkin’s and aggressive non-Hodgkin’s lymphoma may be futile. Conclusion: The yearly ASCOm has become a relevant venue for the presentation, discussion and spread of worthwhile research in hematologic oncology.
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