Genotyping lung adenocarcinoma : from bench to bedside.

Genotipificación del carcinoma de pulmón : del laboratorio al paciente.

Main Article Content

Andrés Felipe Cardona
Hernán Carranza
Luis Gerardo García Herreros
Julio César Granada
Carlos Vargas
Jorge Miguel Otero
Silvia Serrano
July Katherine Rodríguez
Diana Torres
Noemí Reguart
Abstract

Lung cancer harboring mutations in the epidermal growth factor receptor (EGFR) respond to tyrosine kinase inhibitors, but drug resistance invariably emerges. Almost all drug-resistant tumors retained their original activating EGFR mutations, and some acquired known mechanisms of resistance including the EGFR T790M mutation or MET gene amplification. Some resistant cancers showed unexpected genetic changes including EGFR amplification and mutations in the PI3KCA gene, where as others underwent a pronounced epithelial-to-mesenchymal transition. Currently we do not know which is the best treatment for this population so several authors reported the use of EGFR inhibitors plus chemotherapy, chemotherapy alone, radiotherapy or surgery. Some have seen responses with a rechallenge of gefitinib/erlotinib in patients previously responding to these compounds. Here, we report a case that benefited from both these approaches.

Keywords

Downloads

Download data is not yet available.

Article Details

Author Biographies (SEE)

Andrés Felipe Cardona, Fundación Santa Fe de Bogotá ; undación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Hernán Carranza, Fundación Santa Fe de Bogotá ; undación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Luis Gerardo García Herreros, Fundación Santa Fe de Bogotá

Departamento de Cirugía, Sección Cirugía de Tórax, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Julio César Granada, Fundación Santa Fe de Bogotá

Departamento de Cirugía, Sección Cirugía de Tórax, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Carlos Vargas, Fundación Santa Fe de Bogotá ; undación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Jorge Miguel Otero, Fundación Santa Fe de Bogotá ; undación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Silvia Serrano, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

July Katherine Rodríguez, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Diana Torres, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC) ; Pontificia Universidad Javeriana

Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup. Instituto de Genética Humana, Pontificia Universidad Javeriana (Bogotá, Colombia).

Noemí Reguart, ospital Clínico y Provincial de Barcelona

Departamento de Oncología Médica, Sección Oncología Torácica, Hospital Clínico y Provincial de Barcelona (Barcelona, España).

References

Behera D. Managing lung cancer in developing countries: difficulties and solutions. Indian J Chest Dis Allied Sci. 2006;48(4):243-4.

Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108.

Pal SK, Mittal B. Fight against cancer in countries with limited resources: the post-genomic era scenario. Asian Pac J Cancer Prev 2004;5(3):328-33.

Travis WD. Pathology of lung cancer. Clin Chest Med. 2011;32(4):669-92.

Arrieta O, Cardona AF, Federico Bramuglia G, Gallo A, CamposParra AD, Serrano S, et al. Genotyping non-small cell lung cancer (NSCLC) in Latin America. J Thorac Oncol. 2011;6(11):1955-9.

Bria E, Milella M, Cuppone F, Novello S, Ceribelli A, Vaccaro V, et al. Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: a meta-analysis. Ann Oncol. 2011;22(10):2277-85.

Goldberg SB. Chemotherapy with erlotinib or chemotherapy alone in advanced NSCLC with acquired resistance to EGFR tyrosine kinase inhibitors (TKI). J Clin Oncol. 2012;30 (suppl; abstr 7524).

Cardona AF, Moran T, Reguart N, Porta R, Queralt C, Cardenal E, et al. Characteristics and outcomes of non-small cell lung cancer (NSCLC) patients (pts) carrying epidermal growth factor receptor (EGFR) mutations who progress after initial erlotinib (E) response. J Clin Oncol. 2009;27:15s (suppl; abstr 8064).

Enchev S. Bronchoalveolar cancer or pulmonary adenomatosis (Jaagsiekte) of sheep. Neoplasma. 1970;17(4):415-25.

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6(2):244-85.

Livneh O, Hod I, Yegana Y, Mashiah A, Ben-Menahem N, Ron A, et al. Sheep bronchoalveolar carcinoma: tissue associated protein complex (TAPC) in normal lung tissue and in the tumor differed quantitatively. Cancer Detect Prev. 1988;11(3-6):287-96.

Meyers FJ, Madewell BR, Gumerlock PH, DeMartini JC. ras p21 expression in ovine pulmonary carcinoma. Vet Immunol Immunopathol. 1989;23(3-4):279-91.

Humann-Ziehank E, Wolf P, Renko K, Schomburg L, Ludwig Bruegmann M, Andreae A, et al. Ovine pulmonary adenocarcinoma as an animal model of progressive lung cancer and the impact of nutritional selenium supply. J Trace Elem Med Biol. 2011;25 Suppl 1:S30-4.

Kitamura H, Okudela K. Bronchioloalveolar neoplasia. Int J Clin Exp Pathol 2010;4(1):97-9.

Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361(10):947-57.

Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009;361(10):958-67.

Rosell R, Molina MA, Costa C, Simonetti S, Gimenez-Capitan A, Bertran-Alamillo J, et al. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res. 2011;17(5):1160-8.

Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3(75):75ra26.

Smit EF, Burgers SA, Biesma B, Smit HJ, Eppinga P, Dingemans AM, et al. Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer. J Clin Oncol. 2009;27(12):2038-45.

Georgoulias V, Agelidou A, Syrigos K, Rapti A, Agelidou M, Nikolakopoulos J, et al. Second-line treatment with irinotecan plus cisplatin vs cisplatin of patients with advanced nonsmall-cell lung cancer pretreated with taxanes and gemcitabine: a multicenter randomised phase II study. Br J Cancer. 2005;93(7):763-9.

Yamamoto N, Nakagawa K, Nishimura Y, Tsujino K, Satouchi M, Kudo S, et al. Phase III study comparing second- and thirdgeneration regimens with concurrent thoracic radiotherapy in patients with unresectable stage III non-small-cell lung cancer: West Japan Thoracic Oncology Group WJTOG0105. J Clin Oncol. 2010;28(23):3739-45.

Ohe Y, Ohashi Y, Kubota K, Tamura T, Nakagawa K, Negoro S, et al. Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol. 2007;18(2):317-23.

Han JY, Lim HS, Shin ES, Yoo YK, Park YH, Lee JE, et al. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with nonsmall-cell lung cancer treated with irinotecan and cisplatin. J Clin Oncol. 2006;24(15):2237-44.

Cho BC, Im CK, Park MS, Kim SK, Chang J, Park JP, et al. Phase II study of erlotinib in advanced non-small-cell lung cancer after failure of gefitinib. J Clin Oncol. 2007;25(18):2528-33.

Yokouchi H, Yamazaki K, Kinoshita I, Konishi J, Asahina H, Sukoh N, et al. Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer. BMC Cancer. 2007;7:51.

Wong AS, Seto KY, Chin TM, Soo RA. Lung cancer response to gefitinib, then erlotinib, then gefitinib again. J Thorac Oncol. 2008;3(9):1077-8.

Heon S, Nishino M, Goldberg SB, Porter J, Sequist LV, Jackman DM, et al. Response to EGFR tyrosine kinase inhibitor (TKI) retreatment after a drug-free interval in EGFR-mutant advanced non-small cell lung cancer (NSCLC) with acquired resistance. J Clin Oncol. 2012;30 (suppl; abstr 7525).

Weickhardt AJ, Scheier B, Burke JM, Gan G, Doebele RC, Bunn PA, et al. Continuation of EGFR/ALK inhibition after local therapy of oligoprogressive disease in EGFR mutant (Mt) and ALK+ non-small cell lung cancer (NSCLC). J Clin Oncol. 2012;30 (suppl; abstr 7526).

Yu HA, Sima CS, Cruz AED, Varghese AM, Pietanza MC, Azzoli CG, et al. Local therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors. J Clin Oncol. 2012;30 (suppl; abstr 7527).

Janjigian YY, Groen HJ, Horn L, Smit EF, Fu Y, Wang F, et al. Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol. 2011;29 (suppl; abstr 7525).

OJS System - Metabiblioteca |