Analysis of 1p19q codeletion as a prognostic marker for patients with primary glioblastoma.
Análisis de la codeleción 1p19q como marcador pronóstico en pacientes con glioblastoma primario.
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Background: Deletions on chromosomes 1p and 19q have been shown to correlate with prognosis and chemosensitivity in anaplastic oligodendrogliomas and secondary glioblastoma (GB). However, the impact of these alterations over the main outcomes in Colombian patients is unclear. Materials and methods: To present a detailed analysis of a cohort of 38 patients with primary GB who participated in an exploratory analysis of 1p19q translocations documented by polimerase chain reaction (PCR). Data include the analysis of progression free survival (PFS) and overall survival (OS). Results: Mean age was 60 (SD ± 1) and distribution by gender was homogenous (19 males and 19 females). OS according to the state of 1p and 19q was: 1p(+) (n = 10) 23.6 months (range 10.8-36.4)/1p(-) (n = 28) 15.8 months (2.6-9.0) (p = 0.04) and 19q(+) (n = 12) 7.6 months (4.4-10.7)/19q(-) (n = 26) 10.43 months (1.2-19.6) (p = 0.82). Likewise, for those having 1p(+), PFS was 9.73 months (2.6-53) compared to 1p(-) which was 3.97 months (4.3-15.1) (p = 0.053). Conclusion: We found that 1p(+) influenced OS and PFS in a limited series of patients with primary GB treated with chemo/ radiotherapy in Colombia. Such findings must be validated prospectively but the results suggest that 1p affected the prognosis of non-selected with GB.
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