Advances in the molecular classification of brain tumors
Avances en la clasificación molecular de los tumores cerebrales
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In 1918, Percival Bailey completed his medical training, after which he eagerly pursued the elusive knowledge of brain physiology. Hoping to continue his training, Percival Bailey sent letters to two prominent members of the medical community, one a psychiatrist and the other a neurosurgeon. Harvey Cushing responded first, so Bailey met him at Brigham Hospital in Boston, where he had amassed an extensive repository of brain tumor specimens. As the specimens were evaluated, the two doctors discovered that some aggressive lesions grew rapidly, while others followed a benign course. During macroscopic evaluation, Bailey grouped 400 specimens according to survival time, correlating their appearance with clinical outcomes after the neurosurgical procedure. After two thousand surgeries, Cushing and Bailey demonstrated that the cellular structure of a tumor could guide initial treatment and prognosis.
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