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Hypereosinophilia as the initial sign of B-cell acute lymphoblastic leukemia: case report
Hipereosinofilia como manifestación inicial de leucemia linfoblástica aguda de células B: reporte de un caso
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Salehji Bhana A, González G, Tikamdas S, Chevasco Champsaur G, Burrows M, Galego S. Hypereosinophilia as the initial sign of B-cell acute lymphoblastic leukemia: case report. Rev. colomb. hematol. oncol. [Internet]. 2025 Nov. 30 [cited 2025 Dec. 5];12(2):93-8. https://doi.org/10.51643/22562915.779
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How to Cite
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Salehji Bhana A, González G, Tikamdas S, Chevasco Champsaur G, Burrows M, Galego S. Hypereosinophilia as the initial sign of B-cell acute lymphoblastic leukemia: case report. Rev. colomb. hematol. oncol. [Internet]. 2025 Nov. 30 [cited 2025 Dec. 5];12(2):93-8. https://doi.org/10.51643/22562915.779
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Dr. Abdullah Salehji
Roles:
Grettalinha González
Roles:
Siddhartha Tikamdas
Roles:
Gustavo Chevasco Champsaur
Roles:
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Introduction: Hypereosinophilia is rarely associated with B-cell lymphoblastic leukemia (B-ALL) and when presented, it relates to diagnostic delays and an ominous prognosis.
Clinical case: A 24-year-old male presents with a month-long history of anemia, associated with B symptoms, and eosinophilia. Initially managed for intermittent rib pain and during the course of treatment, autoimmune and infectious causes were ruled out. The bone marrow analysis shows signs of B-ALL. Normal cytogenetics. Receives an induction hyperCVAD therapy to remission, with adequate control of the disease. Conclusions: This case highlights the atypical and unusual symptoms associated with eosinophilic infiltration as an initial sign of B-ALL. The prognosis in these cases is poor, associated with the biology of the disease, and on many occasions, diagnostic delays.
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