RANO, más que ficción.
RANO, more than fiction.
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Recientemente, el Grupo de Trabajo en Neurooncología RANO (Response assessment in neuro-oncology) introdujo los criterios para la evaluación de la respuesta de los tumores gliales y su implicación clínica. La creación de esta plataforma y de su primer informe representa un importante paso para precisar la evolución del tratamiento en pacientes con gliomas de alto grado, no solo en el escenario de los ensayos clínicos, sino también en la práctica rutinaria. La terapia antiangiogénica y otras nuevas modalidades de tratamiento han aumentado la incidencia de fenómenos imaginológicos como la pseudoprogresión y la pseudorrespuesta. Igualmente, los nuevos criterios de la RANO toman en cuenta parámetros clínicos como el uso de esteroides y la presencia de síntomas neurológicos. Es importante que los neurorradiólogos, oncólogos y neurooncólogos conozcan estos criterios y adquieran experiencia en su aplicación correcta. Por otra parte, es necesaria más investigación que permita incluir nuevas técnicas de imagen, como la perfusión, difusión y espectroscopia, en el futuro próximo.
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