Peritonectomía radical y quimioterapia intraperitoneal : cinco años de experiencia en la Fundación Santa Fe de Bogotá (ONCOLGroup - estudio ATIA).

Peritoneal cytoreductive surgery and intraperitoneal chemotherapy : five years of experience at the Fundación Santa Fe de Bogotá (ONCOLGroup - ATIA study).

Publicado 2013-03-01

Abrir | Descargar
PDF FLIP
Número
Vol. 2 Núm. 1 (2013): Marzo
Sección
Artículos originales
Cómo citar
Peritonectomía radical y quimioterapia intraperitoneal : cinco años de experiencia en la Fundación Santa Fe de Bogotá (ONCOLGroup - estudio ATIA).
Rev. colomb. hematol. oncol. [Internet]. 2013 Mar. 1 [cited 2024 Dec. 26];2(1):22-33. Disponible en: https://doi.org/10.51643/22562915.328
DOI

https://doi.org/10.51643/22562915.328
Dimensions
PlumX
Licencia
Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.

Jorge Miguel Otero
Fundación Santa Fe de Bogotá
    Fernando Arias
    Fundación Santa Fe de Bogotá
      Eduardo Londoño
      Fundación Santa Fe de Bogotá
        Martha Mora
        Fundación Santa Fe de Bogotá
          Henry Becerra
          Fundación Santa Fe de Bogotá
            Mostrar biografía de los autores

            Jorge Miguel Otero,

            Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Sección Enfermedades del Peritoneo, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Fernando Arias,

            Sección Enfermedades del Peritoneo, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Eduardo Londoño,

            Sección Enfermedades del Peritoneo, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Martha Mora,

            Sección Enfermedades del Peritoneo, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Henry Becerra,

            Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia)

            Natalia Cortés,

            Departamento de Cirugía, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Ómar Salamanca,

            Sección Enfermedades del Peritoneo, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Departamento de Medicina Interna, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Carlos Guerrero,

            Sección Enfermedades del Peritoneo, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Departamento de Anestesiología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Hernán Carranza,

            Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer – FICMAC (Bogotá, Colombia).

            Carlos Vargas,

            Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer – FICMAC (Bogotá, Colombia).

            Laura Bernal,

            Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia)

            Andrés Felipe Cardona,

            Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Sección Enfermedades del Peritoneo, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Objetivo: Evaluar varios desenlaces tempranos en una cohorte de pacientes con neoplasias del peritoneo tratados con peritonectomía radical seguida de quimioterapia hipertérmica intraperitoneal (hyperthermic intraperitoneal chemotherapy, HIPEC). Métodos: Se incluyeron 48 pacientes tratados consecutivamente con peritonectomía radical más HIPEC, entre noviembre de 2007 y junio de 2012; 34 pacientes (70,8%) presentaron tumores de origen apendicular, 6 (12,5%) fueron primarios del peritoneo, 3 (6,3%) de ovario, 3 (6,3%) de colon, 1 carcinosarcoma (2,1%) y 1 (2,1%) angiosarcoma. La edad promedio fue 51 años (±13,1) y la mediana de seguimiento 30 meses (r, 1-46). Se valoraron diversos datos demográficos, la histología, el índice de carcinomatosis peritoneal (PCI), las características de los procedimientos quirúrgicos y varios desenlaces, como la supervivencia libre de recaída (SLR) y la global (SG). También, se determinó la morbilidad y mortalidad a corto plazo. Resultados: En 34 pacientes se logró realizar citorreducción completa (71%). El PCI promedio fue 18 (<_x0031_0: _x0032_7_x002c_2_x0025_ y>10: 70,8%) y la mediana para el tiempo quirúrgico, la estancia en UCI, la duración del soporte nutricional y el tiempo de estancia hospitalaria fueron 14,1 horas (±3,2), 9,3 días (±7), 12,8 días (±9,6) y 29,5 días (±18,6), respectivamente. Las complicaciones más frecuentes fueron eventos tromboembólicos (31%), bacteremia relacionada con catéter (23%), las fístulas (17%), la nefrotoxicidad (17%) y la fuga biliar (8,3%). Dos pacientes (4,2%) fallecieron por complicaciones asociadas al procedimiento. Dieciséis pacientes (33%) tuvieron recaída con una mediana de SLR de 20 meses (IC95%, 11,3-28,4). Conclusiones: La cirugía citorreductiva más HIPEC en pacientes bien seleccionados que presentan neoplasias que afectan el peritoneo es un procedimiento que se puede realizar en Colombia con un adecuado perfil de seguridad y eficacia. La mortalidad fue similar a lo reportado en la literatura mundial.

            Visitas del artículo 558 | Visitas PDF 165

            1. Glockzin G, Schlitt HJ, Piso P. Peritoneal carcinomatosis: patients selection, perioperative complications and quality of life related to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. World J Surg Oncol. 2009;7:5.
            2. Sadeghi B, Arvieux C, Glehen O, Beaujard AC, Rivoire M, Baulieux J, et al. Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000;88(2):358-63.
            3. Yan TD, Brun EA, Cerruto CA, Haveric N, Chang D, Sugarbaker PH. Prognostic indicators for patients undergoing cytoreductive surgery and perioperative intraperitoneal chemotherapy for diffuse malignant peritoneal mesothelioma. Ann Surg Oncol. 2007;14(1):41-9.
            4. Moran B, Baratti D, Yan TD, Kusamura S, Deraco M. Consensus statement on the loco-regional treatment of appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei). J Surg Oncol. 2008;98(4):277-82.
            5. Esquivel J, Elias D, Baratti D, Kusamura S, Deraco M. Consensus statement on the loco regional treatment of colorectal cancer with peritoneal dissemination. J Surg Oncol. 2008;98(4):263-7.
            6. Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol. 2007;14(1):128-33.
            7. Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol. 2003;21(20):3737-43.
            8. Yan TD, Edwards G, Alderman R, Marquardt CE, Sugarbaker PH. Morbidity and mortality assessment of cytoreductive surgery and perioperative intraperitoneal chemotherapy for diffuse malignant peritoneal mesothelioma--a prospective study of 70 consecutive cases. Ann Surg Oncol. 2007;14(2):515- 25.
            9. Di Giorgio A, Naticchioni E, Biacchi D, Sibio S, Accarpio F, Rocco M, et al. Cytoreductive surgery (peritonectomy procedures) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of diffuse peritoneal carcinomatosis from ovarian cancer. Cancer. 2008;113(2):315-25.
            10. Hirose K, Katayama K, Iida A, Yamaguchi A, Nakagawara G, Umeda S, et al. Efficacy of continuous hyperthermic peritoneal perfusion for the prophylaxis and treatment of peritoneal metastasis of advanced gastric cancer: evaluation by multivariate regression analysis. Oncology. 1999;57(2):106-14.
            11. Glehen O, Schreiber V, Cotte E, Sayag-Beaujard AC, Osinsky D, Freyer G, et al. Cytoreductive surgery and intraperitoneal chemohyperthermia for peritoneal carcinomatosis arising from gastric cancer. Arch Surg. 2004;139(1):20-6.
            12. Cheong JH, Shen JY, Song CS, Hyung WJ, Shen JG, Choi SH, et al. Early postoperative intraperitoneal chemotherapy following cytoreductive surgery in patients with very advanced gastric cancer. Ann Surg Oncol. 2007;14(1):61-8.
            13. Glehen O, Kwiatkowski F, Sugarbaker PH, Elias D, Levine EA, De Simone M, et al. Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multiinstitutional study. J Clin Oncol. 2004;22(16):3284-92.
            14. Feldman AL, Libutti SK, Pingpank JF, Bartlett DL, Beresnev TH, Mavroukakis SM, et al. Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy. J Clin Oncol. 2003;21(24):4560-7.
            15. Alexander R, Mavroukakis S, Libutti S, Pingpank J, Beresneva T, Marden S, et al. Impact of tumor resection (Rxn) and intraperitoneal (IP) chemotherapy (CHRx) on health related quality of life (HRQL) in patients (Pts) with peritoneal surface malignancies (PSM). Ann Surg Oncol. 2004;11:S109.
            16. McQuellon RP, Loggie BW, Lehman AB, Russell GB, Fleming RA, Shen P, et al. Long-term survivorship and quality of life after cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis. Ann Surg Oncol. 2003;10(2):155-62.
            17. McQuellon RP, Danhauer SC, Russell GB, Shen P, Fenstermaker J, Stewart JH, et al. Monitoring health outcomes following cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis. Ann Surg Oncol. 2007;14(3):1105-13.
            18. McQuellon RP, Russell GB, Shen P, Stewart JH 4th, Saunders W, Levine EA. Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. Ann Surg Oncol. 2008;15(1):125-33.
            19. McQuellon RP, Danhauer SC, Campbell C, Duckworth K, Beard R, Shen P, et al. Assesing depressive symptoms with the Center of Epidemiologic Studies Depression-Scale prior cytoreductive surgery + intraperitoneal hyperthermic chemotherapy. PsychoOncology. 2009;18(S1-S96):S42.
            20. Verwaal VJ, Bruin S, Boot H, van Slooten G, van Tinteren H. 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol. 2008;15(9):2426-32.
            21. Yonemura Y, Bandou E, Kawamura T, Endou Y, Sasaki T. Quantitative prognostic indicators of peritoneal dissemination of gastric cancer. Eur J Surg Oncol. 2006;32(6):602-6.
            22. Bryant J, Clegg AJ, Sidhu MK, Brodin H, Royle P, Davidson P. Systematic review of the Sugarbaker procedure for pseudomyxoma peritonei. Br J Surg. 2005;92(2):153-8.
            23. National Institute for Clinical Excellence (NICE). Complete cytoreduction for pseudomyxoma peritonei (Sugarbaker technique). Disponible en: http://www.nice.org.uk, consulta del 26 de enero del 2011.
            24. Yan TD, Welch L, Black D, Sugarbaker PH. A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma. Ann Oncol. 2007;18(5):827-34.
            25. Esquivel J, Farinetti A, Sugarbaker PH. [Elective surgery in recurrent colon cancer with peritoneal seeding: when to and when not to proceed]. Cancer Therapeutics. 1998;1:321-5.
            26. Sugarbaker PH. Technical procedures. In: Sugarbaker PH, editor. Technical handbook for the integration of cytoreductive surgery and perioperative intraperitoneal chemotherapy into the surgical management of gastrointestinal and gynecologic malignancy. 4th ed. Washington, D.C.: Washington Cancer Institute; 2006. p. 1-22.
            27. Lanuke K, Mack LA, Temple WJ. A prospective evaluation of venous thromboembolism in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Can J Surg. 2009;52(1):18-22.
            28. Sugarbaker PH, Alderman R, Edwards G, Marquardt CE, Gushchin V, Esquivel J, et al. Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy. Ann Surg Oncol. 2006;13(5):635-44.
            29. Smeenk RM, Verwaal VJ, Zoetmulder FA. Toxicity and mortality of cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei--a report of 103 procedures. Eur J Surg Oncol. 2006;32(2):186-90.
            30. Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126(3 Suppl):338S-400S.
            31. Heit JA, Silverstein MD, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med. 2000;160(6):809-15.
            32. Alcalay A, Wun T, Khatri V, Chew HK, Harvey D, Zhou H, et al. Venous thromboembolism in patients with colorectal cancer: incidence and effect on survival. J Clin Oncol. 2006;24(7):1112-8.
            33. Mandalà M, Falanga A, Cremonesi M, Zaccanelli M, Floriani I, Viganò MG, et al. The extension of disease is associated to an increased risk of venous thromboembolism (VTE) in patients with gastrointestinal (GI) carcinoma. Thromb Haemost. 2006;95(4):752-4.
            34. Chua TC, Saxena A, Schellekens JF, Liauw W, Yan TD, Fransi S, et al. Morbidity and mortality outcomes of cytoreductive surgery and perioperative intraperitoneal chemotherapy at a single tertiary institution: towards a new perspective of this treatment. Ann Surg. 2010;251(1):101-6.
            35. Saxena A, Yan TD, Morris DL. A critical evaluation of risk factors for complications after cytoreductive surgery and perioperative intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis. World J Surg. 2010;34(1):70-8.
            36. Saxena A, Chua TC, Yan TD, Morris DL. Postoperative pancreatic fistula after cytoreductive surgery and perioperative intraperitoneal chemotherapy: incidence, risk factors, management, and clinical sequelae. Ann Surg Oncol. 2010;17(5):1302-10.
            37. Kusamura S, Baratti D, Younan R, Laterza B, Oliva GD, Costanzo P, et al. Impact of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy on systemic toxicity. Ann Surg Oncol. 2007;14(9):2550-8.
            38. Galani E, Marx GM, Steer CB, Culora G, Harper PG. Pseudomyxoma peritonei: the ‘controversial’ disease. Int J Gynecol Cancer. 2003;13(4):413-8.
            39. Moran BJ. Establishment of a peritoneal malignancy treatment centre in the United Kingdom. Eur J Surg Oncol. 2006;32(6):614-8.
            40. Mohamed F, Moran BJ. Morbidity and mortality with cytoreductive surgery and intraperitoneal chemotherapy: the importance of a learning curve. Cancer J. 2009;15(3):196-9.
            41. Yan TD, Black D, Savady R, Sugarbaker PH. A systematic review on the efficacy of cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei. Ann Surg Oncol. 2007;14(2):484-92.
            42. Gilly FN, Cotte E, Brigand C, Monneuse O, Beaujard AC, Freyer G, et al. Quantitative prognostic indices in peritoneal carcinomatosis. Eur J Surg Oncol. 2006;32(6):597-601.
            43. Sugarbaker PH. Quantitative prognostic indicators. In: Sugarbaker PH, editor. Technical handbook for the integration of cytoreductive surgery and perioperative intraperitoneal chemotherapy into the surgical management of gastrointestinal and gynecologic malignancy. 4th ed. Washington, D.C.: Washington Cancer Institute; 2006. p. 12-22.
            44. Arias F, Otero J, Guerrero C, et al. Pseudomyxoma peritonei: first cases treated by radical cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Rev Col Cirug. 2009;24(3):10-5.
            45. Ferreira FO, Aguiar JS, Rossi BM, Nakagawa WT, Toshihiko W, Filho D, et al. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy in the treatment of peritoneal dissemination of neoplasias: preliminary results with closed perfusio technique. Appl Cancer Res. 2005;25(2):82-9.
            46. Gori J, Castaño R, Staringer JC, Hãbich D, González Bernaldo de Quiros D, Felci N, et ál. Quimioterapia intraperitoneal con hipertermia en el cáncer de ovario [Intraperitoneal hyperthermic chemotherapy in ovarian cancer treatment]. Obstet Ginecol Latinoam. 2003;61(1):3-11.
            47. Chua T, Liauw W, Saxena A, Al-Mohaimeed K, Fransi S, Zhao J, et al. Evolution of locoregional treatment for peritoneal carcinomatosis: single-center experience of 308 procedures of cytoreductive surgery and perioperative intraperitoneal chemotherapy. Am J Surg. 2011;201(2):149-56.
            48. Sugarbaker P. Evolution of cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis: are there treatment alternatives. Am J Surg. 2011;201(2):157-9.
            49. Chua TC, Yan TD, Saxena A, Morris DL. Should the treatment of peritoneal carcinomatosis by citoreductive surgery and hyperthermic intraperitoneal chemotherapy still be regarded as a highly morbid procedure?: a systematic review of morbidity and mortality. Ann Surg. 2009;249(6):900-7.
            50. Baratti D, Kusamura S, Mingrone E, Balestra MR, Laterza B, Deraco M. Identification of a subgroup of patients at highest risk for complications after surgical cytoreduction and hyperthermic intraperitoneal chemotherapy. Ann Surg. 2012;256(2):334-41.
            51. Kusamura S, Baratti D, Deraco M. Multidimensional analysis of the learning curve for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancies. Ann Surg [online]. 2012 [cited 2013 Jun 26];255(2):348-56. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22202584.
            52. Moradi BN 3rd, Esquivel J. Learning curve in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Surg Oncol [online]. 2009 [cited 2013 Jun 26];100(4):293-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19697425.
            53. Smeenk RM, Verwaal VJ, Zoetmulder FA. Learning curve of combined modality treatment in peritoneal surface disease. Br J Surg [online]. 2007 [cited 2013 Jun 26];94(11):1408-14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17631678.
            54. Kusamura S, Baratti D, Virzì S, Bonomi S, Iusco DR, Grassi A, et al. Learning curve for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancies: analysis of two centres. J Surg Oncol [online] 2013 [cited 2013 Jun 25];107(4):312-9. Available from: http://doi.wiley.com/10.1002/jso.23231.

            Información

            Directorios e indexadores
            Perfil de Google Scholar

            Código QR

            Palabras clave

            Más leídos en los últimos 30 días

            Número actual

            Sistema OJS 3.4.0.7 - Metabiblioteca |