Molecular classification´s diagnostic and prognostic utility in high-grade gliomas.
Utilidad diagnóstica y pronóstica de la clasificación molecular en gliomas de alto grado
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According to the 5th edition (2021) of the World Health Organization Classification of Primary Tumors of the Central Nervous System, to adequately categorize these neoplasms, it is necessary to evaluate both histological and molecular characteristics. Clinical cases: a descriptive study was implemented for a series of 4 cases with histological diagnosis of high-grade glioma, in whom next-generation sequencing was performed, which led to a comparison between methodologies and highlighting the importance of the use of biology molecular basis for the classification of these neoplasms. A modification was generated in the initial taxonomic classification carried out by histopathology, resulting in a change not only in the diagnosis but also in the prognosis. Conclusion: the new molecular classification of high-grade gliomas specifies the diagnosis and prognosis of patients.
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Low JT, Ostrom QT, Cioffi G, Neff C, Waite KA, Kruchko C, et al. Primary brain and other central nervous system tumors in the United States (2014-2018): A summary of the CBTRUS statistical report for clinicians [Internet]. Neuro-Oncol Pract. 2022;9(3):165-82. Disponible en https://doi.org/10.1093/neuonc/noz150
Palacios Paredes LF, Silva C, García Matamoros EK. Gliomas de Alto Grado del Adulto: Biología Molecular (Parte I): Revisión Narrativa [Internet]. Oncol Ecuad. 2020;30(3):249-79. Disponible en https://doi.org/10.33821/494
Gómez Vega JC, Ocampo Navia MI, De Vries E, Feo Lee O. Sobrevida de los tumores cerebrales primarios en Colombia [Internet]. Univ Médica. 2020;61(3). Disponible en:
https://revistas.javeriana.edu.co/index.php/vnimedica/article/view/27985
Valera-Melé M, Mateo Sierra O, Sola Vendrell E, Guzmán de Villoria L. JA, Carvajal Díaz L, Gil de Sagredo del Corral ÓL, et al. Evaluación del impacto del cambio diagnóstico de los gliomas aplicando la nueva clasificación de la OMS de 2016 sobre una serie de casos [Internet]. Neurocirugía. 2019;30(1):19-27. Disponible en https://doi.org/10.1016/j.neucie.2018.09.003
Komori T. Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System [Internet]. Lab Invest. 2022;102(2):126-33. Disponible en https://doi.org/10.1038/s41374-021-00667-6.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary [Internet]. Acta Neuropathol (Berl). 2016;131(6):803-20. Disponible en https://doi.org/10.1007/s00401-016-1545-1.
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary [Internet]. Neuro-Oncol. 2021;23(8):1231-51. Disponible en https://doi.org/10.1093/neuonc/noab106.
Milbury CA, Creeden J, Yip WK, Smith DL, Pattani V, Maxwell K, et al. Clinical and analytical validation of FoundationOne®CDx, a comprehensive genomic profiling assay for solid tumors. Vousden G, editor [Internet]. PLOS ONE. 2022;17(3): e0264138. Disponible en https://doi.org/10.1371/journal.pone.0264138.
WHO, editor. Central nervous system tumours. 5th edition. Lyon: International Agency for Research on Cancer; 2021. 568 p. (World Health Organization Classification of tumours) ISBN-13978-92-832-4508-7.
Merenzon MA, Gómez Escalante JI, Prost D, Seoane E, Mazzón A, Rojas Bilbao É. Algoritmo para el diagnóstico integrado de los gliomas 2021. Nuestra experiencia [Internet]. Medicina (B Aires). 2022;82(3):370-375. PMID: 35639057.
Sharaf R, Pavlick DC, Frampton GM, Cooper M, Jenkins J, Danziger N, et al. FoundationOne CDx testing accurately determines whole arm 1p19q codeletion status in gliomas [Internet]. Neuro-Oncol Adv. 2021;3(1):vdab017. Disponible en https://doi.org/10.1093/noajnl/vdab017.
Omuro A. Glioblastoma and Other Malignant Gliomas: A Clinical Review [Internet]. JAMA. 2013;310(17):1842. Disponible en https://doi:10.1001/jama.2013.280319.
Whitfield BT, Huse JT. Classification of adult‐type diffuse gliomas: Impact of the World Health Organization 2021 update [Internet]. Brain Pathol. 2022;32(4). Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/bpa.13062
