Relation neutrophils-lymphocytes in solid tumors. Relación neutrófilos-linfocitos en tumores sólidos.

Abstract

Background: The association between cancer and inflammation has aroused great interest in recent years. The neutrophil/ lymphocyte ratio (NLR) has been used as a prognostic value and clinical outcome in cancer. Objective: To determine the high NLR (>2.5) with the clinical stage, metastasis and other markers of severity in patients with solid tumors. Methods: Analytical cross-sectional study, including 170 clinical histories of patients with solid tumors, not exposed to chemotherapy, describing the clinical characteristics and the association of the NLR with the clinical stage, histological type, and degree of differentiation, molecular profile and metastasis. The analyzes were performed with logistic regression, Stata version 12.0. Results: 76% women, median of 63 years, breast cancer 61.1%, prostate 12.3%, colon 15.8%, lung 5.8% and ovary 4.7%. The NLR>2.5 was associated with advanced stage of disease (III and IV) OR: 6.38 (IC95% 1.67-24.4) p=0.007 and OR 4.6 (IC95% 1.13-19) p=0.033 respectively, poorly differentiated tumors OR 2.91 (IC95% 1.01-4.5) p = 0.046 and visceral metastasis OR=4.7 (IC95% 2.2-9.9) p=0.000. No association was found between the NLR and the histological type, molecular profile in breast cancer, Gleason scale in prostate cancer, or bone metastasis. Conclusions: Elevated neutrophil/lymphocyte radius was associated in this study with advanced stage of disease, poorly differentiated tumors and visceral metastasis. It is necessary to expand the sample in order to confirm these results, and in the future, perform studies that relate to therapeutic efficacy.