Stage of disease, hormone receptors and HER2 overexpression : prognostic factors for breast cancer in a cohort of Bogotá (2005-2013). Estadio de la enfermedad, receptores hormonales y sobreexpresión de HER2 : factores pronósticos en cáncer de seno para una cohorte de Bogotá (2005-2013).

Abstract

Background: Breast carcinoma has the highest incidence and mortality in women worldwide and is of great importance to know how the stage of disease at diagnosis, the presence of hormone receptors and HER2 overexpression affect disease-free survival and overall survival in our population. Methods: 228 medical records of an oncological center of Bogotá, Colombia from January 2005 to December 2013 were reviewed, a survival analysis with Kaplan-Meier method, log-rank test and Cox regression was performed. Results: The median follow-up time was 49.6 months (4 years), 76.8% of patients were diagnosed in early stages (I and II) and 22.8% overexpressing HER2. Disease-free survival at five years was 83.7% and overall survival was 92.5%. The degree of differentiation III (HR:4.11; 95% CI:1.8-9.6), overexpression of HER2 (HR:2.41; 95% CI:1.1-5.6) and ≥4 involved nodes (HR:3.01; 95% CI:1.3-7.1) were risk factors for local or systemic relapse with positive estrogen receptors as a protective factor (HR:0.71; 95% CI:0.01-0.46). While positive estrogen receptors were a protective factor for death (HR:0.39; 95% CI:0.002-0.5). Conclusion: The degree of differentiation, HER2 status and number of lymph nodes involved are predictors of disease-free survival, while the hormone receptor status is a predictor of overall survival.