Survival of young women with breast cancer in a colombian referral cancer center between 2007-2016.
Supervivencia de mujeres jóvenes con cáncer de mama en el Instituto de Cancerología Las Américas entre 2007 y 2016.
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Background. The incidence of breast cancer in young women in Latin America is about 20%, and in Colombia, it is around 10% to 24%. Its aggressive behavior is likely due to advance stages at diagnosis and a major frequency of triple negative and Her2-positive subtypes. Objective. This study describes the overall survival (OS) of women ≤40 years old with infiltrating breast cancer that underwent breast surgery between 2007-2016 at the Institute de Cancerología Las Américas auna (Medellín-Colombia). Materials and methods: This is a retrospective observational study. We performed a survival analysis using the Kaplan-Meier method and compared the survival curves using the Log-Rank test. We calculated OS from the date of diagnosis of breast cancer to the date of the last clinic visit or date of death. We compared our results to those reported by other countries in the literature. Results. Of 4059 women who underwent breast surgery, 390 (9.6%) were ≤40 years-old, and 365 patients met inclusion criteria. At diagnosis 67 patients (18.3%) were stage I, 152 (41.6%) stage II, 140 (38.3%) stage III and 6 (1.6%) stage IV. According to the molecular intrinsic subtypes 87 (24.1%) were Luminal A, 152 (42.1%) Luminal B Her2-negative, 72 (19.9%) Luminal B Her2-positive, 17 (4.7%) Her2-enriched and 33 (9.1%) Triple Negative. Loco-regional relapse was seen in 34 patients (9.3%) and 132 (36.2%) developed systemic disease. The median OS time was 60 months (range: 8-142 months), with an OS of 81.3% (IC95%: 76.3-85.4). Patients who had Triple Negative disease had the lowest 5-year OS (67.7%, IC95%: 48-81.3). Conclusions. Patient characteristics differ from what is reported in other countries, in the higher percentage of patients with Luminal B and Her2-positive tumors and the lower proportion of Triple Negative tumors. The OS according to the cancer staging and the molecular subtypes was similar to other countries.
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