Leucemia de células peludas en un hospital de tercer nivel en Bogotá: una serie de casos

Laura Juliana Páez Zamora; María Alejandra  Amín Rojas; Jorge Elías Ochoa Martínez; Maria Helena  Zappa Jaimes; Jheremy Enrique Reyes Castellanos

doi:10.51643/22562915.768

Hairy cell leukemia in a tertiary hospital in Bogotá: a case series

Leucemia de células peludas en un hospital de tercer nivel en Bogotá: una serie de casos

Published 2025-11-30

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Páez Zamora LJ, Amín Rojas MA, Ochoa Martínez JE, Zappa Jaimes MH, Reyes Castellanos JE. Hairy cell leukemia in a tertiary hospital in Bogotá: a case series. Rev. colomb. hematol. oncol. [Internet]. 2025 Nov. 30 [cited 2025 Dec. 5];12(2):64-7. https://doi.org/10.51643/22562915.768

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Vol. 12 No. 2 (2025): Julio-diciembre

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Clinic cases

How to Cite

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Páez Zamora LJ, Amín Rojas MA, Ochoa Martínez JE, Zappa Jaimes MH, Reyes Castellanos JE. Hairy cell leukemia in a tertiary hospital in Bogotá: a case series. Rev. colomb. hematol. oncol. [Internet]. 2025 Nov. 30 [cited 2025 Dec. 5];12(2):64-7. https://doi.org/10.51643/22562915.768

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https://doi.org/10.51643/22562915.768

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Laura Juliana Páez Zamora

Universidad El Bosque

Roles:

https://orcid.org/0000-0003-3437-875X

María Alejandra Amín Rojas

Universidad El Bosque

Roles:

https://orcid.org/0009-0003-7103-3854

Jorge Elías Ochoa Martínez

Universidad El Bosque

Roles:

https://orcid.org/0009-0008-9200-870X

Maria Helena Zappa Jaimes

Universidad El Bosque

Roles:

https://orcid.org/0009-0005-5888-6531

Jheremy Enrique Reyes Castellanos

COBOS MEDICAL CENTER

Roles:

Perfil Google Scholar

https://orcid.org/0000-0002-0082-0477

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Laura Juliana Páez Zamora,

Médica, Universidad El Bosque

María Alejandra Amín Rojas,

Estudiante de Medicina.

Jorge Elías Ochoa Martínez,

Estudiante de Medicina.

Maria Helena Zappa Jaimes,

Médica Epidemióloga.

Jheremy Enrique Reyes Castellanos,

Médico Internista, Hematólogo.

hairy cell leukemia

cytopenia

cladribine

Introduction: Hairy cell leukemia (HCL) is a malignant neoplasm of B lymphocytes. Histologically, it is characterized by lymphocytes with multiple hair-like projections. Its immunophenotype is positive for CD123, CD103, CD25, CD11c, annexin A and its genotype presents a somatic mutation in the BRAFV600E gene. It is considered a rare disease, accounting for only 2% of all leukemias. However, there are few epidemiological data in Colombia. Clinical cases: we present four cases of patients diagnosed with PCL who were managed with the standard protocol cladribine-rituximab in an institution in the city of Bogotá. This work seeks to provide information to local epidemiology and raise awareness of the disease. Conclusion: the complete remission of the disease in the present case series is consistent with the evidence available in the literature. Studies with greater statistical power are needed to more accurately assess the therapeutic response to this protocol and the detection of minimal residual disease.

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Wörmann B, Bohn JP, Dietrich S, Jirse N, Jöhrens K, Krause B, et al. Onkopedia guidelines [Internet]. 2022. Disponible en: https://www.onkopedia-guidelines.info/en/onkopedia/guidelines/hairy-cell-leukemia/@@guideline/html/index.html
Grever M. Leucemia de células peludas clásica. Enciclopedia de Orphanet. [Internet]. Abril, 2020. Disponible en: https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=ES&Expert=58017
Bustamante A, Rodríguez MA, Oqueteau M, Bertín P, Lira P, Valbuena J. Leucemia de células velludas en el embarazo: Caso clínico. Rev Méd Chile [Internet]. 2010;138(11):1422-1426. Disponible en: http://dx.doi.org/10.4067/S0034-98872010001200012. DOI: https://doi.org/10.4067/S0034-98872010001200012
Janus A, Robak T. Hairy Cell Leukemia. Chapter 3: Hairy Cell Leukemia. In: Li W, editor. Leukemia [Internet]. 2022. Brisbane (AU): Exon Publications. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK586203 DOI: https://doi.org/10.36255/exon-publications-leukemia-hairy-cell-leukemia
Maître E, Cornet E, Troussard X. Hairy cell leukemia: 2020 update on diagnosis, risk stratification, and treatment. American Journal of Hematology [Internet]. 2019;94(12):1413-22. Disponible en: https://dx.doi.org/10.1002/ajh.25653 DOI: https://doi.org/10.1002/ajh.25653
Garza-Ledezma MA, Tellez-Hinojosa CA, González-López EE, Gómez-Almaguer D. Hairy cell leukemia, an uncommon B-cell lymphoid neoplasia. Elsevier, Medicina Universitaria [Internet]. 2015;18(70):34-41. Disponible en: https://dx.doi.org/10.1016/j.rmu.2015.12.002 DOI: https://doi.org/10.1016/j.rmu.2015.12.002
Pattnaik SA, Padhi S, Chhabra G, et al. Atypical presentation of hairy cell leukemia: a report and comprehensive review. Blood Res [Internet]. 2020;55:123-127. Disponible en: https://dx.doi.org/10.5045/br.2020.2020069 DOI: https://doi.org/10.5045/br.2020.2020069
Kraut EH. Clinical manifestations and infectious complications and infectious complications of hairy-cell leukaemia. Best practice and Research Clinical Haematology [Internet] 2003; 16(1):33-40. Disponible en: https://doi.org/10.1016/S1521-6926(02)00085-3 DOI: https://doi.org/10.1016/S1521-6926(02)00085-3
Robak T, Matutes E, Catovsky D, Zinzani PL, Buske C. Hairy cell leukemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of oncology. Haematological Malignancies [Internet]. 2015;26(5):100-107. Disponible en: https://www.annalsofoncology.org/article/S0923-7534(19)47171-8/fulltext DOI: https://doi.org/10.1093/annonc/mdv200
Falini B, Tiacci E, Liso A, Basso K, Sabattini E, Pacini R, et al. Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1). Lancet [Internet]. 2004;363(9424):1869-70. Disponible en: https://doi.org/10.1016/S0140-6736(04)16356-3 DOI: https://doi.org/10.1016/S0140-6736(04)16356-3
Parry-Jones N, Anurag J, Forconi F, Dearden C. Guideline for diagnosis and management of hairy cell leukaemia (HCL) and hairy cell variant (HCL-V). British Journal of Haematology [Internet]. 2022;191(5):730-737. Disponible en: https://doi.org/10.1111/bjh.17055 DOI: https://doi.org/10.1111/bjh.17055
Grever MR, Abdel-Wahab O, Andritsos LA, Banerji V, et al. Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia. Blood [Internet]. 2016;129(5):553-560. Disponible en: https://doi.org/10.1182/blood-2016-01-689422 DOI: https://doi.org/10.1182/blood-2016-01-689422
Kreitman RJ, Arons E. Update on hairy cell leukemia. Clin Adv Hematol Oncol [Internet]. 2018;16(3):205-215. Disponible en https://pmc.ncbi.nlm.nih.gov/articles/PMC6290912/
Sigal D, Sharpe R, Burian C y Saven A. Very long-term eradication of minimal residual disease in patients with hairy cell leukemia after single course of cladribine. Blood [Internet]. 2010;115(10):1893-1896. Disponible en https://doi.org/10.1182/blood-2009-10-251645 DOI: https://doi.org/10.1182/blood-2009-10-251645
Wierda WG, Byrd JC, Abramson JS, et al. Hairy Cell Leukemia, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. JNCCN [Internet]. 2018;15(11):1414-1427. Disponible en: https://doi.org/10.6004/jnccn.2017.0165 DOI: https://doi.org/10.6004/jnccn.2017.0165