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Small cell lung cancer: case report with complete clinical response to chemoimmunotherapy
Carcinoma de pulmón de célula pequeña: reporte de un caso con respuesta clínica completa al tratamiento con quimioinmunoterapia
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Osma Charris HR, González Hurtado D, Alzate S, Lasso Carlosama M. Small cell lung cancer: case report with complete clinical response to chemoimmunotherapy. Rev. colomb. hematol. oncol. [Internet]. 2025 Jun. 27 [cited 2025 Dec. 5];12(1):163-74. https://doi.org/10.51643/22562915.709
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Osma Charris HR, González Hurtado D, Alzate S, Lasso Carlosama M. Small cell lung cancer: case report with complete clinical response to chemoimmunotherapy. Rev. colomb. hematol. oncol. [Internet]. 2025 Jun. 27 [cited 2025 Dec. 5];12(1):163-74. https://doi.org/10.51643/22562915.709
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Introduction: Small cell lung carcinoma (SCLC) accounts for 15% of lung cancer cases. It is classified as extensive stage (ES-SCLC) when there is metastasis or if the volume of disease cannot be covered in a single radiotherapy field. Two-thirds of cases present with extensive disease and therefore with a poor prognosis. Despite achieving high objective response rates (ORR) to treatment, complete response (CR) rates do not exceed 3% and the vast majority of patients relapse early. Currently, immunotherapy, especially PD-1 axis blockade in combination with platinum-based chemotherapy is the standard of care. Clinical case: 57-year-old patient with stage ES-SCLC who achieved CR after four cycles of chemoimmunotherapy with durvalumab and carboplatin + etoposide, which is maintained after twenty-two months of treatment. Conclusion: A relationship has been found between ORR and survival, but it is unknown whether CR can be a surrogate for overall survival in SCLC in the era of immunotherapy. In this case, the absence of poor prognostic factors such as extra-thoracic metastatic disease probably favored CR. Biomarkers such as PD-L1 and TMB currently do not allow for treatment selection. In transcriptomic studies, the inflamed subtype (SCLC-I) appears to have a greater benefit from immunotherapy, however it requires prospective validation studies.
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- Globocan. Lung Cancer Fact Sheet. [Internet] Int Agency Res Cancer, World Health Organization; 2022. Consultado el 18 abril de 2024. Disponible en: https://gco.iarc.who.int/media/globocan/factsheets/cancers/15-trachea-bronchus-and-lung-fact-sheet.pdf
- Globocan. World Fact Sheet. [Internet]. Int Agency Res Cancer, World Health Organization; 2022. Consultado el 18 abril de 2024. Disponible en: https://gco.iarc.who.int/media/globocan/factsheets/populations/900-world-fact-sheet.pdf
- Gazdar AF, Bunn PA, Minna JD. Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer [Internet]. 2017 Dec;17(12):725-737. Disponible en: https://doi.org/10.1016/j.jdmv.2020.03.002 DOI: https://doi.org/10.1038/nrc.2017.87
- Zugazagoitia J, Paz-Ares L. Extensive-Stage Small-Cell Lung Cancer: First-Line and Second-Line Treatment Options. J Clin Oncol [Internet]. 2022 Feb 20;40(6):671-680. Disponible en: https://doi.org/10.1016/10.1200/JCO.21.01881 DOI: https://doi.org/10.1200/JCO.21.01881
- Micke P, Faldum A, Metz T, Beeh KM, Bittinger F, Hengstler JG, et al. Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer--what limits limited disease? Lung Cancer [Internet]. 2002 Sep;37(3):271-6. Disponible en: https://doi.org/10.1016/s0169-5002(02)00072-7 DOI: https://doi.org/10.1016/S0169-5002(02)00072-7
- Vallières E, Shepherd FA, Crowley J, Van Houtte P, Postmus PE, Carney D, Chansky K, Shaikh Z, Goldstraw P; International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions. The IASLC Lung Cancer Staging Project: proposals regarding the relevance of TNM in the pathologic staging of small cell lung cancer in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol [Internet]. 2009 Sep;4(9):1049-59. Disponible en: https://doi.org/10.1097/JTO.0b013e3181b27799 DOI: https://doi.org/10.1097/JTO.0b013e3181b27799
- Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA. Cancer J Clin [Internet]. 2022;72(1):7-33. Disponible en: https://doi.org/10.3322/caac.21708 DOI: https://doi.org/10.3322/caac.21708
- Horn L, Mansfield AS, Szczęsna A, Havel L, Krzakowski M, Hochmair MJ, et al. IMpower133 Study Group. First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer. N Engl J Med [Internet]. 2018 Dec 6;379(23):2220-2229. Disponible en: https://doi.org/10.1056/NEJMoa1809064 DOI: https://doi.org/10.1056/NEJMoa1809064
- Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, et al. CASPIAN investigators. Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial. Lancet [Internet]. 2019 Nov 23;394(10212):1929-1939. Disponible en: https://doi.org/10.1016/S0140-6736(19)32222-6 DOI: https://doi.org/10.1016/S0140-6736(19)32222-6
- Invima.gov.co [Internet]. Consulta datos de producto. Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA). Consultado el 20 de abril de 2024. Disponible en: https://consultaregistro.invima.gov.co/Consultas/consultas/consreg_encabcum.jsp
- Rudin CM, Awad MM, Navarro A, Gottfried M, Peters S, Csőszi T, et al. KEYNOTE-604 Investigators. Pembrolizumab or Placebo Plus Etoposide and Platinum as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: Randomized, Double-Blind, Phase III KEYNOTE-604 Study. J Clin Oncol [Internet]. 2020 Jul 20;38(21):2369-2379. Disponible en:https://doi.org/10.1200/JCO.20.00793 DOI: https://doi.org/10.1200/JCO.20.00793
- Liu SV, Dziadziuszko R, Sugawara S, Kao S, Hochmair M, Huemer F, et al. Five-Year Survival in Patients with ES-SCLC Treated with Atezolizumab in IMpower133: Imbrella a Extension Study Results. Journal of Thoracic Oncology [Internet]. 2023;18(11):S44-S45. Disponible en: https://doi.org/10.1016/j.jtho.2023.09.025 DOI: https://doi.org/10.1016/j.jtho.2023.09.025
- Reinmuth N, Goldman JW, Garassino MC, Chen Y, Hotta K, Poltoratskiy A et al. Durvalumab (D) ± tremelimumab (T) + platinum-etoposide (EP) in 1L extensive-stage (ES) SCLC: Characteristics of long-term survivors in the CASPIAN study. Ann Oncol [Internet]. 2022;33(suppl 2): S97-S98 (abstr 1410). Disponible en: https://www.annalsofoncology.org/article/S0923-7534(22)00288-5/fulltext DOI: https://doi.org/10.1016/j.annonc.2022.02.172
- Liu SV, Mok TSK, Nabet BY, Mansfield AS, De Boer R, Losonczy G, et al. Clinical and molecular characterization of long-term survivors with extensive-stage small cell lung cancer treated with first-line atezolizumab plus carboplatin and etoposide. Lung Cancer [Internet]. 2023 Dec;186:107418. Disponible en: https://doi.org/j.lungcan.2023.107418 DOI: https://doi.org/10.1016/j.lungcan.2023.107418
- Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, et al. Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities. Cancer Cell [Internet]. 2021 Mar 8;39(3):346-360.e7. Disponible en: https://doi.org/10.1016/j.ccell.2020.12.014 DOI: https://doi.org/10.1016/j.ccell.2020.12.014
- Hotta K, Kiura K, Fujiwara Y, Takigawa N, Oze I, Ochi N, et al. Association between incremental gains in the objective response rate and survival improvement in phase III trials of first-line chemotherapy for extensive disease small-cell lung cancer. Ann Oncol [Internet]. 2009 May;20(5):829-34. Disponible en: https://doi.org/10.1093/annonc/mdp020 DOI: https://doi.org/10.1093/annonc/mdp020
- Johal S, Fischer C, Cawston H, Jiang H, Brannman L. (EP14.04-002). The Impact of Response on Survival in Extensive Stage Small-Cell Lung Cancer in the CASPIAN Study. ePoster. Presented at the IASLC 2022 World Conference of Lung Cancer (WCLC); Viena, Austria. 6-9 Aug 2022. Disponible en: https://education.iaslc.org/Users/ChromelessAssetSingleViewer.aspx?LearningActivityAssetID=YykV0KhUw1Ao55kXJRASYQ%3d%3d&FromLearningActivityAssetItemForList=1
- Howlader N, Forjaz G, Mooradian MJ, Meza R, Kong CY, Cronin KA, et al. The Effect of Advances in Lung-Cancer Treatment on Population Mortality. N Engl J Med. 2020 Aug 13;383(7):640-649. Disponible en: https://doi.org/10.1056/NEJMoa1916623 DOI: https://doi.org/10.1056/NEJMoa1916623
- Goldman JW, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, et al. CASPIAN investigators. Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial. Lancet Oncol [Internet]. 2021 Jan;22(1):51-65. Disponible en: https://doi.org/10.1016/S1470-2045(20)30539-8 DOI: https://doi.org/10.1016/S1470-2045(20)30539-8
- Paz-Ares L, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, et al. Durvalumab, with or without tremelimumab, plus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer: 3-year overall survival update from CASPIAN. ESMO Open [Internet]. 2022 Apr;7(2):100408. Disponible en: https://doi.org/10.1016/j.esmoop.2022.100408 DOI: https://doi.org/10.1016/j.esmoop.2022.100408
- Vince M, Naqvi SMH, Pellini B, Verbosky M, Melzer D. Real-world comparison of the efficacy and safety of atezolizumab versus durvalumab in extensive-stage small cell lung cancer. Lung Cancer [Internet]. 2024 Dec;198:107999. Disponible en: https://doi.org/10.1016/j.lungcan.2024.107999 DOI: https://doi.org/10.1016/j.lungcan.2024.107999
- Tendler S, Grozman V, Lewensohn R, Tsakonas G, Viktorsson K, De Petris L. Validation of the 8th TNM classification for small-cell lung cancer in a retrospective material from Sweden. Lung Cancer [Internet]. 2018 Jun;120:75-81. Disponible en: https://doi.org/10.1016/j.lungcan.2018.03.026 DOI: https://doi.org/10.1016/j.lungcan.2018.03.026
- Shirasawa M, Fukui T, Kusuhara S, Hiyoshi Y, Ishihara M, Kasajima M, et al. Prognostic significance of the 8th edition of the TNM classification for patients with extensive disease small cell lung cancer. Cancer Manag Res [Internet]. 2018 Nov 21;10:6039-6047. Disponible en: https://doi.org/10.2147/CMAR.S181789 DOI: https://doi.org/10.2147/CMAR.S181789
- Solomon BJ, Loong HH, Summers Y, Thomas ZM, French P, Lin BK, et al. Correlation between treatment effects on response rate and progression-free survival and overall survival in trials of targeted therapies in molecularly enriched populations. ESMO Open [Internet]. 2022 Apr;7(2):100398. Disponible en: https://doi.org/j.esmoop.2022.100398 DOI: https://doi.org/10.1016/j.esmoop.2022.100398
- Goulart BHL, Mushti SL, Chatterjee S, Larkins E, Mishra-Kalyani PS, Pazdur R, et al. Correlations of response rate and progression-free survival with overall survival in immunotherapy trials for metastatic non-small-cell lung cancer: an FDA pooled analysis. Lancet Oncol [Internet]. 2024 Apr;25(4):455-462. Disponible en: https://doi.org/10.1016/S1470-2045(24)00040-8 DOI: https://doi.org/10.1016/S1470-2045(24)00040-8
- Liu SV, Reck M, Mansfield AS, Mok T, Scherpereel A, Reinmuth N, et al. Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133). J Clin Oncol [Internet]. 2021 Feb 20;39(6):619-630. Disponible en: https://doi.org/10.1200/JCO.20.01055 DOI: https://doi.org/10.1200/JCO.20.01055
- Paz-Ares L, Garassino MC, Chen Y, Reinmuth N, Hotta K, Poltoratskiy A, et al. Durvalumab ± Tremelimumab + Platinum-Etoposide in Extensive-Stage Small Cell Lung Cancer (CASPIAN): Outcomes by PD-L1 Expression and Tissue Tumor Mutational Burden. Clin Cancer Res [Internet]. 2024 Feb 16;30(4):824-835. Disponible en: https://doi.org/10.1158/1078-0432.CCR-23-1689 DOI: https://doi.org/10.1158/1078-0432.CCR-23-1689
- Lantuejoul S, Sound-Tsao M, Cooper WA, Girard N, Hirsch FR, Roden AC, et al. PD-L1 Testing for Lung Cancer in 2019: Perspective From the IASLC Pathology Committee. J Thorac Oncol [Internet]. 2020 Apr;15(4):499-519. Disponible en: https://doi.org/10.1016/j.jtho.2019.12.107 DOI: https://doi.org/10.1016/j.jtho.2019.12.107
- Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, et al. New Approaches to SCLC Therapy: From the Laboratory to the Clinic. J Thorac Oncol [Internet]. 2020 Apr;15(4):520-540. Disponible en: https://doi.org/10.1016/j.jtho.2020.01.016 DOI: https://doi.org/10.1016/j.jtho.2020.01.016
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