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Bilateral high-flow chylothorax and chylous ascites as the initial manifestation of follicular-type non-Hodgkin lymphoma

Quilotórax bilateral de alto flujo y ascitis quilosa como manifestación inicial de linfoma no Hodgkin tipo folicular




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Clinic cases

How to Cite
Bilateral high-flow chylothorax and chylous ascites as the initial manifestation of follicular-type non-Hodgkin lymphoma.
Rev. colomb. hematol. oncol. [Internet]. 2024 Dec. 5 [cited 2024 Dec. 22];11(2):84-92. Disponible en: https://doi.org/10.51643/22562915.686

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Natalia Cordoba Pulido,

Médica Internista, Fellow Infectología. Servicio de Medicina Interna, Clínica del Occidente.


Laura Katherine Rodriguez Prieto,

Médica general, Médica hospitalización, Servicio de Medicina Interna, Clínica del Occidente.


Chylothorax and chylous ascites are rare pathologies, with a high rate of mortality if untreated promptly, mostly associated with an active oncology disease.  In the current evidence, we found just a few case reports and observational studies.  Clinical case: We report a case of a 66-year-old woman, who presents with a chylothorax and possible chylous ascites, CT scan showed para- aortic mass and immunohistochemical analysis showed a follicular lymphoma. Regarding the chylothorax, we discuss the diversity of their clinical characteristics, limitations of the diagnosis, treatment possibilities and facilitating pathophysiological mechanisms. Conclusion: In the context of non-traumatic chylothorax, clinical suspicion, early diagnosis and timely management are essential given the high mortality described when left untreated.


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  1. Morjaria JB, Aslam I, Johnson B, Greenstone MA, Kastelik JA. Bilateral chylothorax: an unusual complication of cervical rib resection. Therapeutic Advances In Chronic Disease [Internet]. 23 de septiembre de 2014;6(1):29-33. Disponible en: https://doi.org/10.1177/2040622314552072
  2. Ryu JH, Doerr CH, Fisher SD, Olson EJ, Sahn SA. Chylothorax in Lymphangioleiomyomatosis. CHEST Journal [Internet]. 1 de febrero de 2003;123(2):623-7. Disponible en: https://doi.org/10.1378/chest.123.2.623
  3. Nair SK, Petko M, Hayward MP. Aetiology and management of chylothorax in adults. European Journal Of Cardio-Thoracic Surgery [Internet]. 19 de junio de 2007;32(2):362-9. Disponible en: https://doi.org/10.1016/j.ejcts.2007.04.024
  4. Mahajan A, Sankhyan P, Boonpheng B. Bilateral Chylothorax and Chylous Ascites: A Rare Presentation of an Uncommon Disorder. Cureus [Internet]. 22 de marzo de 2021;13(3): e14044. Disponible en: https://doi.org/10.7759/cureus.14044
  5. Kako S, Joshita S, Matsuo A, Kawaguchi K, Umemura T, Tanaka E. A Case of Adult T-Cell Leukemia/Lymphoma Complicated with Bilateral Chylothorax. Case Reports In Oncological Medicine [Internet]. 17 de febrero de 2019;2019:1-5. Disponible en: https://doi.org/10.1155/2019/8357893
  6. Podder S, Mora M, Patel V, Sivamurthy S. A rare case of bilateral chylothorax: a diagnostic challenge—follicular lymphoma versus primary effusion lymphoma. BMJ Case Reports [Internet]. 17 de agosto de 2015;bcr2015211935. Disponible en: https://doi.org/10.1136/bcr-2015-211935
  7. Hori H, Tanaka Y, Nakayama R, Nohgawa M. CD56-positive Angioimmunoblastic T-cell Lymphoma Complicated by Chylothorax. Internal Medicine [Internet]. 30 de agosto de 2021;61(5):729-33. Disponible en: https://doi.org/10.2169/internalmedicine.7783-21
  8. Armas Moredo K, Santos Herrera Y, Olivera Morán OE, García Rodríguez ME, Armas Pérez BA. Quilotórax bilateral y linfoma simultáneo en dos varones: presentación de dos casos. Archivo Médico de Camagüey [Internet]. 2014;18(1):110-123. Recuperado de: https://www.redalyc.org/articulo.oa?id=211131570012
  9. Jiménez CE. Ascitis quilosa: Presentación de un caso y revisión de la fisiopatología. Revista Colombiana de Cirugía. 2004;19(2):76-84. Disponible en: https://www.revistacirugia.org/index.php/cirugia/article/view/1352/1015
  10. Wijaya SY, Koesoemoprodjo W. Indonesian female with bilateral chylothorax and mediastinal non-Hodgkin lymphoma: A case report. International Journal Of Surgery Case Reports [Internet]. 1 de diciembre de 2022;102:107827. Disponible en: https://doi.org/10.1016/j.ijscr.2022.107827
  11. Paul T, Yadav DK, Alhamar M, Dabak V. Primary Pleural Extranodal Marginal Zone Lymphoma Presenting as Bilateral Chylothorax. Case Reports In Oncology [Internet]. 30 de julio de 2020;13(2):929-34. Disponible en: https://doi.org/10.1159/000508704.
  12. Pérez R, Peláez R, Rosales P, Holguín V, Campos R. Quilotórax secundario a enfermedad de Hodgkin. Enfermedades Emergentes. 2010;12(3):162-166. Disponible en: http://enfermedadesemergentes.com/articulos/a645/ee-12-3-007.pdf
  13. Batista JL, Birmann BM, Epstein MM. Epidemiology of Hematologic Malignancies. En: Springer eBooks [Internet]; 2016, p. 543-69. Disponible en: https://doi.org/10.1007/978-3-319-35153-7_29
  14. Smith A, Howell D, Patmore R, Jack A, Roman E. Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network. British Journal Of Cancer [Internet]. 1 de noviembre de 2011;105(11):1684-92. Disponible en: https://doi.org/10.1038/bjc.2011.450
  15. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA A Cancer Journal For Clinicians [Internet]. 4 de febrero de 2021;71(3):209-49. Disponible en: https://doi.org/10.3322/caac.21660
  16. Cuenta de Alto Costo. Consenso basado en evidencia. Indicadores de gestión del riesgo en pacientes con linfoma No Hodgkin y linfoma Hodgkin en Colombia [En línea]; 2018, p. 1-114. Disponible en: https://cuentadealtocosto.org/site/wp-content/uploads/2019/10/indicadores_gestion_del_riesgo_adultos_con_Linfoma_no_Hodgkin_y_Linfoma_Hodgkin_Colombia.pdf
  17. Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS. Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood [Internet]. 9 de septiembre de 2005;107(1):265-76. Disponible en: https://doi.org/10.1182/blood-2005-06-2508
  18. Laurini JA, Perry AM, Boilesen E, Diebold J, MacLennan KA, Müller-Hermelink HK, et al. Classification of non-Hodgkin lymphoma in Central and South America: a review of 1028 cases. Blood [Internet]. 20 de octubre de 2012;120(24):4795-801. Disponible en: https://doi.org/10.1182/blood-2012-07-440073
  19. Armitage JO, Gascoyne RD, Lunning MA, Cavalli F. Non-Hodgkin lymphoma. The Lancet [Internet]. 31 de enero de 2017;390(10091):298-310. Disponible en: https://doi.org/10.1016/s0140-6736(16)32407-2
  20. Macfarlane JR, Holman CW. Chylothorax. PubMed [Internet]. 1 de febrero de 1972;105(2):287-91. Disponible en: https://pubmed.ncbi.nlm.nih.gov/5066693
  21. Allen CJ, DiPasco PJ, Koshenkov V, Franceschi D. Non-Hodgkin’s Lymphoma as a Risk Factor for Persistent Chylothorax After Transhiatal Esophagectomy. World Journal Of Oncology [Internet]. 1 de enero de 2012; Disponible en: https://doi.org/10.4021/wjon523w
  22. Maranatha D, Bestari B. Problema Diagnostik dan Respons Kemoterapi pada Seorang Penderita Classical Limfoma Hodgkin Tipe Mixed Cellularity dengan Temporary Spontaneus Regression. Jurnal Respirasi [Internet]. 22 de abril de 2019;3(1):7. Disponible en: https://doi.org/10.20473/jr.v3-i.1.2017.7-11
  23. Staats BA, Ellefson RD, Budahn LL, Dines DE, Prakash UB, Offord K. The lipoprotein profile of chylous and nonchylous pleural effusions. Mayo Clin Proc. 1980 Nov;55(11):700-4. Disponible en: https://pubmed.ncbi.nlm.nih.gov/7442324/
  24. Maldonado F, Hawkins FJ, Daniels CE, Doerr CH, Decker PA, Ryu JH. Pleural Fluid Characteristics of Chylothorax. Mayo Clinic Proceedings [Internet]. 30 de enero de 2009;84(2):129-33. Disponible en: https://doi.org/10.4065/84.2.129
  25. Janjetovic S, Janning M, Daukeva L, Bokemeyer C, Fiedler W. Chylothorax in a Patient with Hodgkin’s Lymphoma: A Case Report and Review of the Literature. Tumori Journal [Internet]. 1 de mayo de 2013;99(3):e96-9. Disponible en: https://doi.org/10.1177/030089161309900324
  26. Doerr CH, Miller DL, Ryu JH. Chylothorax. Seminars In Respiratory And Critical Care Medicine [Internet]. 1 de enero de 2001;22(06):617-26. Disponible en: https://doi.org/10.1055/s-2001-18797
  27. Gibbons SM, Ahmed F. Chylothorax diagnosis: can the clinical chemistry laboratory do more? Annals Of Clinical Biochemistry International Journal Of Laboratory Medicine [Internet]. 8 de abril de 2014;52(1):173-6. Disponible en: https://doi.org/10.1177/0004563214530677
  28. Park JG, Aubry MC, Godfrey JA, Midthun DE. Mediastinal Lymphangioma: Mayo Clinic Experience of 25 Cases. Mayo Clinic Proceedings [Internet]. 1 de septiembre de 2006;81(9):1197-203. Disponible en: https://doi.org/10.4065/81.9.1197
  29. Schild HH, Strassburg CP, Welz A, Kalff J. Treatment Options in Patients With Chylothorax. Deutsches Ärzteblatt International [Internet]. 29 de noviembre de 2013;110(48): 819-26. Disponible en: https://doi.org/10.3238/arztebl.2013.0819
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