Gestational trophoblastic neoplasia, a case report.

Neoplasia trofoblástica gestacional, a propósito de un caso

Published 2024-06-30

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Vol. 11 No. 1 (2024): Enero-junio
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Clinic cases
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Gestational trophoblastic neoplasia, a case report.
Rev. colomb. hematol. oncol. [Internet]. 2024 Jun. 30 [cited 2025 Jan. 2];11(1):58-66. Disponible en: https://doi.org/10.51643/22562915.668
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https://doi.org/10.51643/22562915.668
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Hernán Darío Jaramillo Calderon
Fundación Cancerológica Clínica Vida, Medellín, Colombia.
    Susana Sepúlveda Tamayo
    Clínica del Prado
      Ana María Sierra
      Fundación Universitaria Autónoma De Las Américas image/svg+xml
        https://orcid.org/0000-0001-9979-328X
        Jhon Alexander Cañas Gallego
        Fundación Cancerológica Clínica Vida
          David Alejandro Vásquez Chaverra
          Clínica del Prado
            Show authors biography

            Hernán Darío Jaramillo Calderon,

            Médico, Fundación Cancerológica Clínica Vida.

            Susana Sepúlveda Tamayo,

            Médica, Clínica del Prado.

            Ana María Sierra,

            Médica general, Magister en Educación para Profesionales de la Salud. En formación actual como Especialista en Gerencia Educativa. Fundación Universitaria Autónoma de las Américas/Institución Universitaria Visión de las Américas.

            Jhon Alexander Cañas Gallego,

            Oncólogo clínico, Fundación Cancerológica Clínica Vida.

            David Alejandro Vásquez Chaverra,

            Médico, Clínica del Prado.

            Gestational Trophoblastic Neoplasia encompasses a broad spectrum of invasive placental diseases, including invasive mole, choriocarcinoma, placental site tumor, and epithelioid trophoblastic tumor. Clinical case: In this report, we analyze the clinical case of a 26-year-old postpartum patient who was diagnosed late with choriocarcinoma due to low clinical suspicion and an unusual presentation of the disease. The aim of this work is to raise awareness among readers about the importance of establishing a precise and timely diagnosis of GTN. Additionally, a thorough discussion of the topic will be conducted, providing insights for early disease diagnosis and classification to reduce associated complications.

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            1. Vree M, van Trommel N, Kenter G, Sweep F, ten Kate-Booij M, Massuger L, Lok C. The influence of lung metastases on the clinical course of gestational trophoblastic neoplasia: A historical cohort study. BJOG: An International Journal of Obstetrics & Gynaecology [Internet]. 2015;123(11):1839-1845. Disponible en: https://doi.org/10.1111/1471-0528.13622
            2. Creasman J, Mannell W, McMeekin R, Mutch DG. Clinical gynecologic oncology. Elsevier [Internet]. 2018;143:79-85. Disponible en: https://www.scopus.com/record/display.uri?eid=2-s2.0-85042793053&origin=inward&txGid=30d7562d99d9e117f512a8c816ebbcfd
            3. Devita V, Lawrence T, Rosenberg S. Cancer. Principles & Practice of Oncology (10th Edition). Wolters Kluwer Health. 1069 (2015).
            4. Taylor S, Eisenstein K, Gildenstern V, Price H, Hingorani P, Patel A, Page N, Bailey S, Carpentieri D. Metastatic choriocarcinoma masquerading as a congenital glabellar hemangioma. Pediatric and Developmental Pathology [Internet]. 2018;22(1):59-64. Disponible en: https://doi.org/10.1177/1093526618765039
            5. Ngan H, Seckl M., Berkowitz R, Xiang Y, Golfier F, Sekharan P K, Lurain J R, Massuger L. Update on the diagnosis and management of gestational trophoblastic disease. International Journal of Gynecology and Obstetrics [Internet]. 2018;143: 79-85. Disponible en: https://doi.org/10.1002/ijgo.12615
            6. Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I. Genomic profile in gestational and non-gestational choriocarcinomas. Placenta [Internet]. 2017;50:8-15. Disponible en: https://doi.org/10.1016/j.placenta.2016.12.009
            7. Candelier J, Frappart L, Diatta A, Yadaden T, Cissé M, Afoutou J, Picard J, Mennesson B, Slim R, Si-Tayeb K, Coullin P. Differential expression of E-cadherin, β-catenin, and Lewis X between invasive hydatidiform moles and post-molar choriocarcinomas. Virchows Archiv [Internet]. 2013;462(6):653-663. Disponible en: https://doi.org/10.1007/s00428-013-1427-z
            8. Hui P. Gestational trophoblastic tumors: A timely review of diagnostic pathology. Archives of Pathology; Laboratory Medicine [Internet]. 2018;143(1):65-74. Disponible en: https://doi.org/10.5858/arpa.2018-0234-ra
            9. Clark J, Slater S, Seckl M. Treatment of gestational trophoblastic disease in the 2020s. Current Opinion in Obstetrics and Gynecology [Internet]. 2020;33(1):7-12. Disponible en: https://doi.org/10.1097/gco.0000000000000674
            10. Lawrie TA, Alazzam M, Tidy J, Hancock BW, Osborne R. First-line chemotherapy in low-risk gestational trophoblastic neoplasia. Cochrane Database Syst Rev [Internet]. 2016;2019(6):CD007102. Disponible en: http://dx.doi.org/10.1002/14651858.CD007102.pub4
            11. Horowitz NS, Eskander RN, Adelman MR, Burke W. Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: A Society of Gynecologic Oncology evidenced-based review and recommendation. Gynecologic Oncology. 2021 Dec;163(3):605-13.
            12. Al Riyami N, Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman, Al Riyami M, Al Hajri AT, Al Saidi S, Salman B, et al. Gestational trophoblastic disease at sultan Qaboos university hospital: Prevalence, risk factors, histological features, sonographic findings, and outcomes. Oman Med J [Internet]. 2019;34(3):200-4. Disponible en: http://dx.doi.org/10.5001/omj.2019.39
            13. Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P. Gestational trophoblastic disease: an update. Abdom Radiol (NY) [Internet]. 2023;48(5):1793-815. Disponible en: https://pubmed.ncbi.nlm.nih.gov/36763119/
            14. Soper, J. Gestational trophoblastic disease: Current evaluation and management. Obstetrics and Gynecology [Internet]. 2021;137(2):355-370. Disponible en: https://doi.org/10.1097/aog.0000000000004240
            15. Eysbouts Y, Bulten J, Ottevanger P, Thomas C, ten Kate-Booij, M van Herwaarden, A Massuger. Trends in incidence for gestational trophoblastic disease over the last 20years in a population-based study. Gynecologic Oncology [Internet] 2016;140(1):70–75. Disponible en: https://doi.org/doi:10.1016/j.ygyno.2015.11.01410.1016/j.ygyno.2015.11.014
            16. Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P. Gestational trophoblastic disease: an update. Abdom Radiol (NY) [Internet]. 2023;48(5):1793-815. Disponible en: https://pubmed.ncbi.nlm.nih.gov/36763119/
            17. Mangili G, Lorusso D, Brown J, Pfisterer J, Massuger L, Vaughan M, et al. Trophoblastic Disease review for diagnosis and management: A joint report from the International Society for the study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer [Internet]. 2014;24(Supp 3):S109–16. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25341573/
            18. Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, Sessa C. Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol [Internet]. 2013;24:vi39–50. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23999759/

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