Clinical and cytogenetic pattern in patients with myelodysplasic syndrome in Cúcuta (Norte de Santander, Colombia).

Patrón clínico y citogenético en pacientes con síndrome mielodisplásico en Cúcuta (Norte de Santander, Colombia).

Published 2018-07-01

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Vol. 5 No. 1 (2018): Julio
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Clinical and cytogenetic pattern in patients with myelodysplasic syndrome in Cúcuta (Norte de Santander, Colombia).
Rev. colomb. hematol. oncol. [Internet]. 2018 Jul. 1 [cited 2024 Dec. 22];5(1):10-6. Disponible en: https://doi.org/10.51643/22562915.355
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Juan Carlos Serrano Casas
Unidad Hematológica Especializada
    Carlos Roberto Varón Jaimes
    Unidad Hematológica Especializada
      Ana Teresa Govin
      Unidad Hematológica Especializada
        Gabriel Celis
        Unidad Hematológica Especializada
          Luz Karine Maldonado
          Unidad Hematológica Especializada
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            Juan Carlos Serrano Casas,

            Médico cirujano, especialista en Medicina Interna y Hematología. Unidad Hematológica Especializada. Cúcuta (UHE) (Colombia).

            Carlos Roberto Varón Jaimes,

            Médico cirujano, especialista en Medicina Interna y Hematología. Director Médico, Unidad Hematológica Especializada. Cúcuta (UHE) (Colombia).

            Ana Teresa Govin,

            Médico cirujano, especialista en Medicina Interna y Hematología. Servicio de Hematología, Unidad Hematológica Especializada. Cúcuta (UHE) (Colombia).

            Gabriel Celis,

            Bacteriólogo. Departamento de Citogenética, Unidad Hematológica Especializada. Cúcuta (UHE) (Colombia).

            Luz Karine Maldonado,

            Bacterióloga. Departamento de Citogenética, Unidad Hematológica Especializada. Cúcuta (UHE) (Colombia).

            Javier Pacheco,

            Médico cirujano, especialista en Medicina Interna y Oncohematología. Departamento de Oncología, Hospital San José de Bogotá.

            Myelodysplastic syndromes (MDS) are clonal neoplasms of variable prognosis according to stratification. Cytogenetics is key in diagnosis and prognosis. Population and methods: At UHE we studied 81 patients with MDS. Clinical characterization, laboratory, IPSS-R, mortality, cytogenetic analysis with description of typical clonal anomalies and atypical SMD. Results: Mean age 71 years, with female predominance. Most frequent subtype was SMD with multilineage dysplasia and unilineal dysplasia, anemia was the most common manifestation. Higher proportion of low and intermediate risk cases (IPSS-R). Mean follow-up did not show differences between groups (p = 0.18). Overall 5-year survival was 79%. Progression to AML in 9.8%. Increased number of deaths in very high (85%) and high risk (50%) groups. Cytogenetics with 72% mitotic index at 24 hours. Clonal karyotype 43% with 53 alterations of 81 studies, being complex in 8.6%. (5q) and -Y 6.1%, (20q), (11q), (17p) and +8 in 3.7%. We found cytogenetic abnormalities not typical of MDS as: -22, -13-11, from (10q), 14p+, 15q+ at 1.2%. Conclusions: Subtypes of MDS, cytopenias, IPSS-R, mortality, structural and numerical cytogenetic alterations; correlate with the literature. Presence of atypical cytogenetic alterations deserves more evaluation and expansion in international database.

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