Citations
Antiplatelet action over the platelet count in platelet-rich plasma.
Acción de los antiagregantes plaquetarios sobre el recuento de plaquetas en el plasma rico en plaquetas.
Open | Download
How to Cite
1.
González M, Arteaga Vizcaíno M, Ruiz A, Esis D, González B, Rosmary Galue R, et al. Antiplatelet action over the platelet count in platelet-rich plasma. Rev. colomb. hematol. oncol. [Internet]. 2013 Jul. 1 [cited 2025 Dec. 5];2(2):15-22. https://doi.org/10.51643/22562915.340
Download Citation
Section
Original articles
How to Cite
1.
González M, Arteaga Vizcaíno M, Ruiz A, Esis D, González B, Rosmary Galue R, et al. Antiplatelet action over the platelet count in platelet-rich plasma. Rev. colomb. hematol. oncol. [Internet]. 2013 Jul. 1 [cited 2025 Dec. 5];2(2):15-22. https://doi.org/10.51643/22562915.340
Dimensions
license
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Show authors biography
Objective: Evaluate the platelet count in the platelets-rich plasma (PRP) from healthy subjects before and after the administration of antiplatelet agents. Material and method: It is studied 32 subjects, 20 female and 12 male, between 18 and 50 years old and apparently healthy. They were distributed in two groups: 1) 16 subjects who received aspirin (100 mg) and 2) 16 with clopidogrel (75 mg), these doses were unique for a day. In each subject is extracted 16,5 ml of venous blood antecubital for platelet count in peripheral blood and PRP, platelet aggregation before treatment is practiced. Results: In all the studied subjects are found a platelet count before treatment with antiplatelet in peripheral blood of 276,55 ± 66,43 x mm3 and 24 hours after 281,38 ± 81,55 x mm3. In the PRP of subjects before to receiving aspirin was 566,86 ± 109,16 x mm3 and then 526,34 ± 90,55 x mm3; prior to clopidogrel ingestion was 444,76 ± 100,65 x mm3 and 388,82 ± 71,94 x mm3 after treatment. Significant differences for the platelet count were found only for clopidogrel (p < 0,05). The correlation for the count of platelets before and after the treatment only exists for aspirin (r = 0,88). Conclusions: In this study showed a significant decrease in the platelet count after administering clopidogrel without correlation between them before and after treatment. Further studies are necessary to evaluate a larger number of cases and their effect on platelet aggregation.
Article visits 778 | PDF visits 413
Downloads
Download data is not yet available.
- Campbell NA. Biología. 8a ed. Londres: Editorial Pearson; 2008.
- Hilman R, Kenneth A, Henry M. Hematología en la práctica clínica. 4ª ed. Editorial Manual Moderno; 2005.
- Patrono C, Bachmann F, Baigent C, Bode C, De Caterina R, Charbonnier B et ál. Grupo de trabajo sobre el uso de agentes antiplaquetarios en pacientes con enfermedad cardiovascular aterosclerótica de la Sociedad Europea de Cardiología. Documento de consenso de expertos sobre el uso de agentes antiplaquetarios. Rev Esp Cardiol. 2004;57:963-80.
- Harker LA, Boissel JP, Pilgrim AJ, Gent M. Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidrogel versus aspirin in patients at risk of ischaemic events. Drug Saf. 1999;21(4):325-35.
- Tanasescu S, Lévesque H, Thuillez C. Farmacología de la aspirina. Rev Med Int. 2000;21:(1):18s-26s.
- Hayasaka M, Takahashi Y, Nishida Y, Yoshida Y, Hidaka S, Asai S. Comparative effect of clopidogrel plus aspirin and aspirin monotherapy on hematological parameters using propensity score matching. Vasc Health Risk Manag. 2013;9:65-70.
- Cohen Arazimtsac H, Carnevalini M, Falconi E, Ovejero R, Giorgimtsac M, Carolimtsac C et ál. Relación entre el efecto antiagregante de la aspirina y el recuento plaquetario. Posibles implicaciones en la dosificación. Rev Argent Cardiol. 2012;80:114-20.
- Hernández R, Fernández C, Baptista LP. Metodología de la investigación. 4ª ed. Iztapalapa-México D.F.: Editorial McGrawHill; 2006.
- Arias FG. El proyecto de investigación. Introducción a la metodología científica. 5ª ed. Caracas: Editorial Episteme; 2006.
- Born GV. Aggregation of blood platelets by adenosine and its reversal. Nature. 1962;194:927-9.
- Anitua E. La utilización de los factores de crecimiento plasmáticos en cirugía oral, maxilofacial y periodoncia. RCOE. 2001;6(3):305-15.
- Ware JA, Coller BS. Platelet morphology, biochemistry and function. In: Beutler E, Lichtman MA, Coller BS, editors. Williams hematology. 5th ed. New York: McGraw-Hill; 1995. p. 1161-201.
- Bick RL. Platelet function defects. In: Bick RL, editor. Disorders of thrombosis and hemostasis: clinical and laboratory practice. USA: Lippincott Williams & Wilkins; 2002. p. 59-90.
- Daniel W. Estadística con aplicaciones a las ciencias sociales y la educación. México, D.F.: McGraw-Hill; 1988.
- Molina V, Arruzazabala L, Carbajal D, Más R. Farmacología de los agentes antiagregantes plaquetarios. Revista Cenic Ciencias Biológicas. 2005;36(1):3-12.
- Buss DH, Cashell AW, O’Connor ML, Richards F 2nd, Case LD. Occurrence, etiology, and clinical significance of extreme thrombocytosis: a study of 280 cases. Am J Med. 1994;96(3):247-53.
- Bizzozero J. On a new blood particle and its role in thrombosis and blood coagulation. Virchows Arch Pathol Anat Physiol Clin Med. 1882;90:261-332.
- Folman CC, Ooms M, Kuennen BB, De Jong SM, Vet RJ, de Haas M, et al. The role of thrombopoietin in post-operative thrombocytosis. Br J Haematol. 2001;114(1):126-33.
- Kaser A, Brandacher G, Steurer W, Kaser S, Offner FA, Zoller H, et al. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Blood. 2001;98(9):2720-5.
- Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev. 2009;23(4):177-89.
- Schrör K. The basic pharmacology of ticlopidine and clopidogrel. Platelets. 1993;4(5):252-61.
Tutorials
About the journal
Information
Directories and Indexers
Plagiarism Check
Descriptor
Google Scholar profile
QR code
Keywords
Most read in the last 30 days
