Pathologic and molecular characteristics of pseudomyxoma peritonei (ONCOLGroup).
Características patológicas y moleculares del pseudomixoma peritoneal (ONCOLGroup).
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Pathologic and molecular characteristics of pseudomyxoma peritonei (ONCOLGroup).
Rev. colomb. hematol. oncol. [Internet]. 2012 Apr. 1 [cited 2024 Dec. 22];1(1):52-9. Disponible en: https://doi.org/10.51643/22562915.288
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Pseudomyxoma peritonei (PMP) is a poorly understood condition characterized by mucinous ascites and multifocal peritoneal mucinous tumors. Several previous histopathological and immunohistochemical studies of PMP have suggested that most, if not all, cases of PMP are derived from mucinous adenomas of the appendix rather than from primary ovarian tumors. A few studies of the molecular genetics of PMP have been recently reported. However, these studies analyzed only a small number of cases and some included a heterogeneous group of mucinous tumors, including both benign and malignant appendiceal and ovarian neoplasms. Previous reports demonstrated K-ras mutations and allelic losses of chromosomes 18q, 17p, 5q, and 6q in a substantial number of morphologically uniform cases of PMP with synchronous ovarian and appendiceal tumors as well as in appendiceal mucinous adenomas and ovarian mucinous tumors of low malignant potential unassociated with PMP. Our review strongly support the conclusion that mucinous tumors involving the appendix and ovaries in PMP are clonal and derived from a single site, most likely the appendix.
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