Diffuse intrinsic pontine glioma : parallel between the child and the adult.
Glioma pontino intrínseco difuso : paralelo entre el niño y el adulto.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Show authors biography
Brainstem tumors account for 10-20% of pediatric brain tumors, diffuse intrinsic pontine glioma is the most common brainstem tumor of childhood. Diffuse intrinsic pontine glioma is a heterogeneous group of tumors that are biologically distinct from other pediatric and adult high grade gliomas. Patients with diffuse intrinsic pontine gliomas have a rapid cranial nerve deficit, paresis or ataxia, the appearance of these lesions on nuclear magnetic resonance is characteristic. Diffuse intrinsic pontine glioma is a therapeutic challenge in neurooncology. Chemotherapy has not proven to be a treatment that stops or slows tumor growth. Radiation therapy is the only valid treatment, but its efficiency is only transient. This article describes two clinical cases involving a pediatric and adult patient, diagnosed with diffuse intrinsic pontine glioma, the purpose is to do a parallel between the cases.
Article visits 814 | PDF visits 752
- Upadhyaya S, Koschmann C, Muraszko K, Venneti S, Garton H, Hamstra D, et al. Brainstem low-grade gliomas in children - Excellent outcomes with multimodality therapy. J Child Neurol. 2017;32(2):194-203.
- Eisele S, Reardon D. Adult brainstem gliomas. Cancer. 2016;122(8):2799-809.
- Klimo P, Nesvick C, Broniscer A, Orr B, Choudhri A. Malignant brainstem tumors in children, excluding diffuse intrinsic pontine gliomas. J Neurosurg Pediatr. 2016;17(1):57-65.
- Reyes G, Mokhtari K, Martin N, Delattre C, Laigle F. Adult brainstem gliomas. The Oncologist. 2012;17(3):388-97.
- Hoffman L, Van Zanten V, Colditz N, Baugh J, Chaney B, Hoffmann M, et al. Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG Registries. J Clin Oncol. 2018;36(19):1963-72.
- Laigle F, Doz F, Delattre J. Brainstem gliomas in children and adults. Curr Opin Oncol. 2008;20(6):662-7.
- Hu J, Western S, Kesari S. Brainstem glioma in adults. Front. Oncol.2016;6(180):1-7.
- Yoshida K, Sulaiman N, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, et al. Radiotherapy for brainstem gliomas in children and adults: a single-institution experience and literature review. Asia Pac J Clin Oncol. 2017;13(2):e153-60.
- Gwak H, Park H. Developing chemotherapy for diffuse pontine intrinsic gliomas (DIPG). Crit Rev Oncol Hematol. 2017;120(3):111-9.
- Vanan M, Eisensta D. DiPG in children – what can we learn from the past? Front Oncol. 2015;5:(237):1-17.
- Lobon M, Santa-María V, Puerta P, Candela S, Ramos M, Gómez M, et al. Tumor dissemination through surgical tracts in diffuse intrinsic pontine glioma. J Neurosurg Pediatr. 2018;22(6):678-83.
Information
