Tumor lysis syndrome in adults : literature review.

Síndrome de lisis tumoral en adultos : revisión de la literatura.

Published 2016-06-01

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Vol. 3 No. 2 (2016): Junio
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Tumor lysis syndrome in adults : literature review.
Rev. colomb. hematol. oncol. [Internet]. 2016 Jun. 1 [cited 2024 Dec. 21];3(2):10-6. Disponible en: https://doi.org/10.51643/22562915.150
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Luisa Galvis
Asociación Colombiana de Hematología y Oncología
    Diego González
    Asociación Colombiana de Hematología y Oncología
      Natallie Jurado
      Asociación Colombiana de Hematología y Oncología
        Jesús Sánchez
        Asociación Colombiana de Hematología y Oncología
          Show authors biography

          Luisa Galvis,

          Médica especialista en formación Oncología Clínica, Instituto Nacional de Cancerología (Bogotá).

          Diego González,

          Médico especialista en Oncología Clínica, Instituto de Cancerología Las Américas (Medellín).

          Natallie Jurado,

          Médica internista Hospital Universitario San Ignacio (Bogotá).

          Jesús Sánchez,

          Médico especialista en Oncología Clínica, Instituto Nacional de Cancerología, Centro Javeriano de Oncología, Pontificia Universidad Javeriana (Bogotá).

          Tumor lysis syndrome (TLS) is an oncologic emergency that is caused by massive tumor cell lysis with the release into the systemic circulation of large amounts of intracellular elements like potassium, phosphate and nucleic acids, causing renal failure, arrhythmias, seizures and death. TLS is more frequent in haematologic neoplasias or with high proliferative rate or highly chemo-sensitive, and usually occurs after 48 hours of the initiation of cytotoxic therapy, rarely spontaneously. The objective of management is prevention, which consists of aggressive hydration and the administration of hypouricemic agents, and the diagnosis should be oriented according to the risk factors associated with the neoplasia and to the patient.

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