piARNs y proteínas similares a PIWI en el Mieloma Múltiple y su futuro como biomarcadores y blancos terapéuticos

piRNAs and PIWI -like proteins in Multiple Myeloma and their future as biomarkers and therapy targets

Publicado 2024-06-30

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Vol. 11 Núm. 1 (2024): Enero-junio
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piARNs y proteínas similares a PIWI en el Mieloma Múltiple y su futuro como biomarcadores y blancos terapéuticos.
Rev. colomb. hematol. oncol. [Internet]. 2024 Jun. 30 [cited 2024 Dec. 21];11(1):67-79. Disponible en: https://doi.org/10.51643/22562915.697
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https://doi.org/10.51643/22562915.697
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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.

Jheremy Sebastian Reyes Barreto
Universidad de Los Andes image/svg+xml
    https://orcid.org/0000-0002-7366-0881
    Leidy Viviana Giron Jurado
    Universidad de Santander
      https://orcid.org/0009-0001-9698-1653
      Maria Paula Montoya Estrada
      Grupo de investigación en cáncer y medicina molecular (CAMMO)
        https://orcid.org/0000-0002-6970-7704
        Iris Lorena Sánchez Moreno
        Grupo de investigación en cáncer y medicina molecular (CAMMO)
          https://orcid.org/0000-0001-6155-5470
          Laura Tatiana Picón Moncada
          Universidad Colegio Mayor de Cundinamarca image/svg+xml
            https://orcid.org/0000-0003-2853-7750
            Mostrar biografía de los autores

            Jheremy Sebastian Reyes Barreto,

            Médico, Universidad de Los Andes, Colombia.

            Leidy Viviana Giron Jurado,

            Médica, Universidad de Santander, Colombia

            Maria Paula Montoya Estrada,

            Bacterióloga y Laboratorista Clínica, Universidad Colegio Mayor de Cundinamarca, Colombia.

            Iris Lorena Sánchez Moreno,

            Bióloga, Universidad Pedagógica y Tecnológica de Colombia.

            Laura Tatiana Picón Moncada,

            Estudiante de Bacteriología y laboratorio clínico, Universidad Colegio Mayor de Cundinamarca, Colombia. Grupo de investigación en cáncer y medicina molecular (CAMMO)

            Karen Luna - Orozco,

            Médica Internista, Magíster en Epidemiología.

            Jhonathan David Guevara Ramirez,

            Estudiante de Ingeniería biomédica, Universidad Militar Nueva Granada.

            Libia Adriana Gaona Fernández,

             Médica Familiar. Grupo de investigación en cáncer y medicina molecular (CAMMO)

            El Mieloma Múltiple (MM) es la segunda neoplasia hematológica más común y uno de los 19 tipos de cáncer más frecuentes. Su diagnóstico es un desafío debido a la baja tasa de reconocimiento de la enfermedad, y los retrasos en el diagnóstico conducen al daño en los órganos característico de la enfermedad. Se requieren nuevos enfoques para abordar este desafío diagnóstico. La evidencia emergente muestra que los ARN interaccionantes con Piwi (piARN) promueven un aumento de la metilación en las células de MM. En este análisis, profundizamos en los últimos descubrimientos sobre la biogénesis y funciones de los piRNA, ofreciendo nuevas perspectivas sobre los posibles usos de piARNs en la detección y diagnóstico en MM. El piARN-823 aumenta en las células de MM y se correlaciona positivamente con la etapa de la enfermedad. Sus acciones tumorigénicas en el MM están relacionadas con la comunicación intercelular entre las células de MM y las células endoteliales de las venas. Estos hallazgos proporcionan la información necesaria para resaltar el posible papel del piARN-823 como biomarcador para el diagnóstico del MM.

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