Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura

Español

Contenido principal del artículo

Óscar Iglesias-Jiménez
Rita Magola Sierra-Merlano
Keyner Toro-Osorio
Resumen

La enfermedad falciforme (EF) comprende un grupo de trastornos hereditarios con expresión clínica heterogénea y múltiples complicaciones de índole vascular y hemolítica. El priapismo representa una emergencia urológica que amerita intervención quirúrgica temprana para disminuir la disfunción eréctil. Objetivos: informar cinco casos de EF atendidos por priapismo en la ESE Hospital Universitario de Cartagena (ESEHUC) resaltando las características sociodemográficas, clínicas y de laboratorio que se asociaron a disfunción eréctil. Métodos: serie de casos hospitalaria. Resultados: se registraron cinco casos de priapismo con mediana calculada para edad de 33 años, IMC: 23 kg/m2, tres casos pertenecieron al subtipo homocigoto, uno doble heterocigoto y un rasgo de la EF. La media de ingreso hospitalario se consideró tardía siendo mayor a 48 horas de evolución del priapismo y en todos se optó por el manejo quirúrgico urológico. Tres casos presentaron disfunción sexual, uno clasificado severo. Conclusiones: los casos con formas subclínicas y genotipos de bajo riesgo pueden enfrentarse a priapismo mayor, con riesgo de padecer complicaciones con impacto sobre la vida sexual. Se insiste en educar a los pacientes sobre la consulta temprana y estilos de vida que
disminuyan el riesgo de priapismo.

Palabras clave

Descargas

Los datos de descargas todavía no están disponibles.

Detalles del artículo

Biografía del autor/a (VER)

Óscar Iglesias-Jiménez, Universidad de Cartagena, Facultad de Medicina. Cartagena, Colombia

Médico. Especialista en Medicina Interna.

Rita Magola Sierra-Merlano, Universidad de Cartagena, Facultad de Medicina. Cartagena, Colombia

Médica. Especialista en Medicina Interna y Reumatología. PhD Ciencias de la Educación. 

Keyner Toro-Osorio, Universidad de Cartagena, Facultad de Medicina. Cartagena, Colombia

Médico. Especialista en Medicina Interna y Vascular.

Referencias

Sundd, Prithu, Gladwin, Mark, Novelli E. Pathophysiology of Sickle Cell Disease [Internet]. Annu Rev Pathol. 2019;14:263–92. Disponible en: https://doi.org/10.1146/annurev-pathmechdis-012418-012838.

Ramírez-cheyne J, Moreno M, Mosquera S, Duque S, Holguín J, Camacho A. Primeros dos años de notificación de las enfermedades huérfanas-raras en Cali e identificación de algunas variables asociadas con la mortalidad. Iatreia. 2020;33(2):111–22. Disponible en: https://doi.org/10.17533/udea.iatreia.37.111

Castillo, Martha, Mora, Ana, Oliveros A. Anemias ferropénicas asociadas a hemoglobinopatías en comunidades afrodescendientes en Colombia. Nova [Internet]. 2018;16(29):33–8. Disponible en: https://hemeroteca.unad.edu.co/index.php/nova/article/view/2687/2827

Anele UA, Le B V, Resar LMS, Burnett AL. How I Treat priapism. Blood. 2015;125(23):3551-8. Disponible en: https://doi.org/10.1182/blood-2014-09-551887

Sampaio P, Milena F, Costa P. The prevalence of priapism in children and adolescents with sickle cell disease in Brazil. Int J Hematol. 2012;95(1):648–51. Disponible en: https://doi.org/10.1007/s12185-012-1083-0

Emond AM, Holman R, Hayes RJ, Serjeant GR. Priapism and Impotence in Homozygous Sickle Cell Disease. Arch Intern M. 2015;140(11):1434–7. Disponible en: https://doi.org/10.1001/archinte.1980.00330220022011

Wang CS, Kao WT, Chen CD, Tung YP, Lung FW. Priapism associated with typical and atypical antipsychotic medications. Int Clin Psychopharmacol [Internet]. 2006;21(4). Disponible en: https://journals.lww.com/intclinpsychopharm/fulltext/2006/07000/priapism_associated_with_typical_and_atypical.8.aspx

Rodríguez Villalba R, García S, Puigvert Martínez A, María Pomerol I Montseny J, Munárriz R. Priapismo. Actas Urológicas Españolas [Internet]. 2005;29(10):961–8. Disponible en: https://doi.org/10.1016/S0210-4806(05)73377-5

Wang Y, Zhang J, Li H. Narrative review: pathogenesis, diagnosis, and treatment of sleep-related painful erection [Internet]. Transl Androl Urol. 2021;10(12). Disponible en: https://tau.amegroups.org/article/view/86178

Broderick GA. Priapism and Sickle-Cell Anemia: Diagnosis and Nonsurgical Therapy [Internet]. J Med. 2012;9(1):88–103. Disponible en: https://doi.org/10.1111/j.1743-6109.2011.02317.x

Raafat M, Mohammed H. Priapism : Current Updates in Clinical Management ; Review article. [Internet] EJHM. 2022;88(1):3661–7. Disponible en: https://doi.org/10.21608/EJHM.2022.249512

Bivalacqua, TJ; Allen, BK; Brock G et al. The diagnosis and management of recurrent ischemic priapism, priapism in sickle cell patients, and non-ischemic priapism: an AUA/SMSNA guideline [Internet]. J Urol. 2022;208(1):43–52.

Ugwumba, FO, Ekwedigwe, HC, Echetabu KN, Okoh, AD, Nnabugwu, I, Ugwuidu E. Ischemic priapism in South ‑ East Nigeria : Presentation , management challenges , and aftermath issues [Internet]. Niger J Clin Pract. 2016;19:207–11. Disponible en: https://doi.org/10.4103/1119-3077.175968

Aldallal S, Aldallal N, Alam A. Sickle cell-induced ischemic priapism [Internet]. Cogent Med. 2017;3(1):1268357. 10.1080/2331205X.2016.1268357

Attar FS, Mohammad MA. Long-term outcome of sexual function in sickle cell disease men with ischemic priapism: A systematic review [Internet]. J Clin Urol. 2021;15(2):114–7. Disponible en: https://doi.org/10.1177/20514158211014051

Okoko AR, Odzébé ASW, Moyen E, Ekouya Bowassa G, Oko APG, Mbika-Cardorelle A, et al. Priapism in children and adolescents with homozygous sickle cell disease in Brazzaville [Internet]. Prog Urol. 2014 Jan;24(1):57–61. Disponible en: https://doi.org/10.1016/j.purol.2013.04.021

Arduini GAO, Marqui ABT De, Arduini GAO, Marqui ABT De. Prevalence and Characteristics of Priapism in Sickle Cell Disease [Internet]. Hemoglobin. 2018;42(2):73–7. Disponible en: https://doi.org/10.1080/03630269.2018.1452760

Mougougou A, Ndang S, Milama N, Ngomas JF, Boumas N, Chimelle F, et al. Management of Priapism in Sickle Cell Patients: Experience of the Urology Department of the University Hospital Centre of Libreville [Internet]. Open J Urol. 2021;11(1):87–94. Disponible en: https://doi.org/10.4236/oju.2021.113009

Idris IM, Burnett AL, Debaun MR. Epidemiology and treatment of priapism in sickle cell disease [Internet]. Hematology. 2022;2022(1):450–8. Disponible en: https://doi.org/10.1182/hematology.2022000380.

Proudman RGW, Pupo AS, Baker JG. The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors [Internet]. Pharmacol Res Perspect. 2022;10(2):e00936. Disponible en: https://doi.org/10.1002/prp2.936

Greiner T, Schneider M, Regente J, Toto S, Grohmann R, Heinze M. Priapism induced by various Psychotropics: A Case Series [Internet]. World J Biol Psychiatry. 2019;20(6):505–12. Disponible en: https://doi.org/10.1080/15622975.2018.1520396

Kamel K, Mohamed M, Abderrazek B, Mohamed C, Amine D, Riadh BS, et al. Prise en charge du priapisme à bas débit vue tardivement: à propos de 28 cas [Internet]. African J Urol. 2016;22(4):297–304. Disponible en: https://doi.org/10.1016/j.afju.2015.10.005

Azbell RCG, Desai PC. Treatment dilemmas: strategies for priapism, chronic leg ulcer disease, and pulmonary hypertension in sickle cell disease [Internet]. Hematol Am Soc Hematol Educ Progr. 2021;1:411–7. Disponible en: https://doi.org/10.1182/hematology.2021000275

Kato GJ, Mcgowan V, Machado RF, Little JA, Vi JT, Morris CR, et al. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease [Internet]. Blood. 2006;107(6):2279–85. Disponible en: https://doi.org/10.1182/blood-2005-06-2373.

Vi JGT, Nolan VG, Mendelsohn L, Kato GJ, Gladwin MT, Steinberg MH. Chronic Hyper-Hemolysis in Sickle Cell Anemia : Association of Vascular Complications and Mortality with Less Frequent Vasoocclusive Pain [Internet]. PLoS One. 2008;3(5):e2095. Disponible en: https://doi.org/10.1371/journal.pone.0002095

Birnbaum BF, Pinzone JJ. Sickle cell trait and priapism: a case report and review of the literature [Internet]. Cases J. 2008;1(1):7–9. 10.1186/1757-1626-1-429

Helvaci MR, Gokce C, Davran R, Akkucuk S, Ugur M, Oruc C. Mortal quintet of sickle cell diseases [Internet]. Int J Clin Exp Med [Internet]. 2015;8(7):11442–8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565344/

Yuan C, Quinn E, Kucukal E, Kapoor S, Umut A, Little JA, et al. Priapism, hemoglobin desaturation, and red blood cell adhesion in men with Sickle Cell Anemia [Internet]. Blood Cells Mol Dis. 2019;79:102350. Disponible en: https://doi.org/10.1016/j.bcmd.2019.102350.

Adeyoju AB, Olujohungbe ABK, Morris J, Yardumian A, Bareford D, Akenova A, et al. Priapism in sickle-cell disease; incidence, risk factors and complications - An international multicentre study [Internet]. BJU Int. 2002;90(9):898–902. Disponible en: https://doi.org/10.1046/j.1464-410X.2002.03022.x

Vilas C, Figueiredo B, Santiago RP, Conceic C, Neres S, Mateus A, et al. Priapism in sickle cell disease : Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers [Internet]. PLoS One. 2021;16(2):e0246067. Disponible en: https://doi.org/10.1371/journal.pone.0246067

Oluwagbemiga O. Adeodu, Morenike A. Akinlosotu SAA and SBAO. Foetal Haemoglobin and Disease Severity in Nigerian Children with Sickle Cell. Mediterr [Internet]. J Hematol Infect Dis. 2017;9(1):1–8. Disponible en: https://doi.org/10.4084/MJHID.2017.063

Alvaia MA, Maia HAA da S, Nelli A de M, Guimarães COS, Carvalho ES de S, Netto JMB, et al. Prevalence of priapism in individuals with sickle cell disease and implications on male sexual function [Internet]. Einstein (Sao Paulo). 2020;18:eAO5070. Disponible en: https://doi.org/10.31744/einstein_journal/2020AO5070

Anele UA, Morrison BF, Burnett AL, Hopkins TJ. Molecular Pathophysiology of Priapism : Emerging Targets [Internet]. Curr Drugs Targets. 2015;16(5):474–83. Disponible en: https://doi.org/10.2174/1389450115666141111111842

Kato GJ. Priapism in Sickle-Cell Disease: A Hematologist’s Perspective [Internet]. J Sex Med. 2012;9(1):70–8. Disponible en: https://doi.org/10.1111/j.1743-6109.2011.02287.x

Nolan VG, Wyszynski DF, Farrer LA, Steinberg MH, Ben BEN, Car BEN, et al. Hemolysis-associated priapism in sickle cell disease data from the Cooperative Study for Sickle [Internet]. Blood. 2005;106(9):3264–7. Disponible en: https://doi.org/10.1182/blood-2005-04-1594.Supported

Alkindi S, Almufargi SS, Pathare A. Clinical and laboratory parameters , risk factors predisposing to the development of priapism in sickle cell patients [Internet]. Biol Med. 2020;245(1):79–83. Disponible en: https://doi.org/10.1177/1535370219892846

Idris IM, Abba A, Galadanci JA, Aji SA, Jibrilla AU, Rodeghier M, et al. Incidence and predictors of priapism events in sickle cell anemia: a diary-based analysis [Internet]. Blood Adv. 2022;6(20):5676–83. Disponible en: https://doi.org/10.1182/bloodadvances.2022007285

Bello A, Maitama HY, Ahmed M, Sudi A. Surgical treatment of priapism in sickle cell patients: A noble therapy in preserving erection [Internet]. Arch Int Surg. 2016;6(1):12–6. Disponible en: https://doi.org/10.4103/2278-9596.187200

Idris IM, Abba A, Galadanci JA, Mashi SA, Hussaini N, Gumel SA, et al. Men with sickle cell disease experience greater sexual dysfunction when compared with men without sickle cell disease [Internet]. Blood Adv. 2020;4(14):3277–83. Disponible en: https://doi.org/10.1182/bloodadvances.2020002062

Sistema OJS - Metabiblioteca |