Response to vismodegib in recurrent meduloblastoma.

Respuesta a vismodegib en un meduloblastoma recurrente.

Contenido principal del artículo

Laura Bernal
Nicolás Useche
Sonia Bermúdez
Andrés Felipe Cardona

Resumen

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Detalles del artículo

Biografía del autor/a (VER)

Laura Bernal, Fundación Santa Fe de Bogotá

Clinical and Translational Oncology Group, Institute of Oncology, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Nicolás Useche, Fundación Santa Fe de Bogotá

Diagnostic Image Department, Neuro-Radiology Section, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Sonia Bermúdez, Fundación Santa Fe de Bogotá

Diagnostic Image Department, Neuro-Radiology Section, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Andrés Felipe Cardona, Fundación Santa Fe de Bogotá ; Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Clinical and Translational Oncology Group, Institute of Oncology, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Foundation for Clinical and Applied Cancer Research (FICMAC); ONCOLGroup associate researcher.

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Referencias (VER)

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Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med. 2009;361(12):1173-8.

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LoRusso PM, Rudin CM, Reddy JC, Tibes R, Weiss GJ, Borad MJ, et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res. 2011;17(8):2502-11.

Gajjar AJ, Amar J. A prospective phase II study to determine the efficacy of GDC 0449 (vismodegib) in adults with recurrent medulloblastoma (MB): A Pediatric Brain Tumor Consortium study (PBTC 25B). J Clin Oncol. 2013; suppl: abstr 2035.

Weiss GJ, Korn RL. Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors. Cancer. 2012;118(21):5310-9.

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