Sarcomagenesis.

Sarcomagénesis.

Contenido principal del artículo

Andrés Felipe Cardona
Jairo Zuluaga
Hernán Carranza
Jorge Miguel Otero
Carlos Vargas

Resumen

Los sarcomas representan un número heterogéneo de neoplasias que surgen de la transformación de algunas células mesenquimales primitivas. La evidencia ha aumentado de forma considerable respecto de las células pluripotenciales que dan origen a estos tumores y que parecen ser responsables de la iniciación, el mantenimiento, la diferenciación y la proliferación del osteosarcoma, sarcoma sinovial, rabdomiosarcoma y del sarcoma de Ewing. Se han adoptado diferentes métodos para la identificación de células primitivas en los sarcomas, tales como el uso de marcadores de superficie, la citometría de flujo para el aislamiento de células con elevada actividad de la aldehído deshidrogenasa y la realización de análisis de población celular. Esta revisión resume y analiza datos sobre la tumorigénesis de los sarcomas, evaluando su posible papel en la sensibilidad y resistencia a diferentes intervenciones clásicas (quimio y radioterapia), así como nuevas terapias dirigidas molecularmente.

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Detalles del artículo

Biografía del autor/a (VER)

Andrés Felipe Cardona, Fundación Santa Fe de Bogotá ; Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Clinical and Translational Oncology Group, Institute of Oncology, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Foundation for Clinical and Applied Cancer Research (FICMAC); associated researcher ONCOLGroup.

Jairo Zuluaga, Fundación Santa Fe de Bogotá

Department of Internal Medicine, Fundación Santa Fe de Bogotá (Bogotá, Colombia)

Hernán Carranza, Fundación Santa Fe de Bogotá ; Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Clinical and Translational Oncology Group, Institute of Oncology, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Foundation for Clinical and Applied Cancer Research (FICMAC); associated researcher ONCOLGroup.

Jorge Miguel Otero, Fundación Santa Fe de Bogotá ; Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Clinical and Translational Oncology Group, Institute of Oncology, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Foundation for Clinical and Applied Cancer Research (FICMAC); associated researcher ONCOLGroup.

Carlos Vargas, Fundación Santa Fe de Bogotá ; Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Clinical and Translational Oncology Group, Institute of Oncology, Fundación Santa Fe de Bogotá (Bogotá, Colombia). Foundation for Clinical and Applied Cancer Research (FICMAC); associated researcher ONCOLGroup.

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Referencias (VER)

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