El papel de Notch, Hh y Wnt en el desarrollo del cáncer de pulmón.
The role of Notch, Hh and Wnt in lung cancer development.
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Hedgehog (Hh), Notch and Wingless-Int (Wnt) are signalling pathways highly conserved among species, essential for embryonic development and progenitor cell fates. All three of these pathways participate in lung development as well as airway epithelial repair process. But interestingly aberrant activation of these pathways is observed in a large variety of cancers, suggesting its potential contribution in the evolution and maintenance of a malignant phenotype. New evidence implicates malignant transformation of the neuroendocrine lineage with aberrant Hedgehog pathway activation, whereas Notch and Wnt signalling may be important in other airway cell types. Bearing in mind the importance of the new theory of tumor formation based on stem-cells rather than on the stochastic model of carcinogenesis, it is not surprising that there has been increasing interest in these genes directly implicated in the stem-cell renewal process. Currently drug design strategies are focus on targeting these signalling pathways and may provide therapeutic opportunities in lung cancer. This review focuses on Hh, Notch Wnt signalling pathways and gives more insight about its role in lung tumorigenesis.
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