Progenitores de los tumores cerebrales.

Stem cells in brain tumors.

Contenido principal del artículo

León Darío Ortiz
Andrés Felipe Cardona
Hernán Carranza
Henry Becerra
Carlos Vargas
Enrique Jiménez
Fernando Hakim
Nicolás Useche
Sonia Bermúdez
Jorge Otero
Pilar Archila
Silvia Serrano
Diana Torres
July Katherine Rodríguez
Orlando Ricaurte
Carmen Balañá
Alejandro Blanco

Resumen

El dogma sobre la génesis de las células es un evento insignificante en el cerebro de los mamíferos adultos, que ha influenciado nuestra percepción y la comprensión del origen y desarrollo de los tumores del sistema nervioso central. El descubrimiento de que las neuronas y la neuroglia se generan a lo largo de la vida a partir de células progenitoras proporciona nuevas posibilidades para definir la clonalidad y el comportamiento de las neoplasias cerebrales. La hipótesis detrás de este hallazgo está soportada por las modificaciones celulares y los mecanismos genéticos que controlan la neurogénesis normal y tumoral, lo que permite la identificación de nuevas estrategias terapéuticas.

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Detalles del artículo

Biografía del autor/a (VER)

León Darío Ortiz, Clínica Las Américas

Departamento de Oncología Clínica, Sección Neuro-oncología, Instituto de Cancerología, Clínica Las Américas (Medellín, Colombia). Investigador asociado Red Latinoamericana de Neurooncología (RedLANO).

Andrés Felipe Cardona, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Investigador asociado Red Latinoamericana de Neurooncología (RedLANO). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Hernán Carranza, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Investigador asociado Red Latinoamericana de Neurooncología (RedLANO). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Henry Becerra, Fundación Santa Fe de Bogotá

Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Carlos Vargas, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Investigador asociado Red Latinoamericana de Neurooncología (RedLANO). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Enrique Jiménez, Fundación Santa Fe de Bogotá

Departamento de Neurocirugía, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Fernando Hakim, Fundación Santa Fe de Bogotá

Departamento de Neurocirugía, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Nicolás Useche, Fundación Santa Fe de Bogotá

Departamento de Imágenes Diagnósticas, Sección Neurorradiología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Sonia Bermúdez, Fundación Santa Fe de Bogotá

Departamento de Imágenes Diagnósticas, Sección Neurorradiología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

Jorge Otero, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Investigador asociado Red Latinoamericana de Neurooncología (RedLANO). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Pilar Archila, Hospital de San José-Fundación Universitaria de Ciencias de la Salud

Departamento de Patología, Hospital de San José, Fundación Universitaria de Ciencias de la Salud (Bogotá, Colombia).

Silvia Serrano, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Diana Torres, Pontificia Universidad Javeriana

Instituto de Genética Humana, Pontificia Universidad Javeriana (Bogotá, Colombia); investigador asociado German Cancer Research Center (DKFZ).

July Katherine Rodríguez, Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)

Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

Orlando Ricaurte, Universidad Nacional de Colombia

Departamento de Patología, Universidad Nacional de Colombia (Bogotá, Colombia).

Carmen Balañá, Hospital Germans Trias i Pujol

Departamento de Oncología Médica, Sección Neuro-oncología, Hospital Germans Trias i Pujol, Instituto Catalán de Oncología (ICO) (Barcelona, España).

Alejandro Blanco, Hospital México

Departamento de Radioterapia, Hospital México (San José de Costa Rica, Costa Rica).

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