Progenitores de los tumores cerebrales.

Stem cells in brain tumors.

Publicado 2012-09-01

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Vol. 1 Núm. 3 (2012): Septiembre
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Progenitores de los tumores cerebrales.
Rev. colomb. hematol. oncol. [Internet]. 2012 Sep. 1 [cited 2024 Dec. 26];1(3):36-50. Disponible en: https://doi.org/10.51643/22562915.312
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León Darío Ortiz
Clínica Las Américas
    Andrés Felipe Cardona
    Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)
      Hernán Carranza
      Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)
        Henry Becerra
        Fundación Santa Fe de Bogotá
          Carlos Vargas
          Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC)
            Mostrar biografía de los autores

            León Darío Ortiz,

            Departamento de Oncología Clínica, Sección Neuro-oncología, Instituto de Cancerología, Clínica Las Américas (Medellín, Colombia). Investigador asociado Red Latinoamericana de Neurooncología (RedLANO).

            Andrés Felipe Cardona,

            Investigador asociado Red Latinoamericana de Neurooncología (RedLANO). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

            Hernán Carranza,

            Investigador asociado Red Latinoamericana de Neurooncología (RedLANO). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

            Henry Becerra,

            Grupo Oncología Clínica y Traslacional, Instituto de Oncología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Carlos Vargas,

            Investigador asociado Red Latinoamericana de Neurooncología (RedLANO). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

            Enrique Jiménez,

            Departamento de Neurocirugía, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Fernando Hakim,

            Departamento de Neurocirugía, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Nicolás Useche,

            Departamento de Imágenes Diagnósticas, Sección Neurorradiología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Sonia Bermúdez,

            Departamento de Imágenes Diagnósticas, Sección Neurorradiología, Fundación Santa Fe de Bogotá (Bogotá, Colombia).

            Jorge Otero,

            Investigador asociado Red Latinoamericana de Neurooncología (RedLANO). Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

            Pilar Archila,

            Departamento de Patología, Hospital de San José, Fundación Universitaria de Ciencias de la Salud (Bogotá, Colombia).

            Silvia Serrano,

            Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

            Diana Torres,

            Instituto de Genética Humana, Pontificia Universidad Javeriana (Bogotá, Colombia); investigador asociado German Cancer Research Center (DKFZ).

            July Katherine Rodríguez,

            Fundación para la Investigación Clínica y Molecular Aplicada del Cáncer (FICMAC); investigador asociado ONCOLGroup.

            Orlando Ricaurte,

            Departamento de Patología, Universidad Nacional de Colombia (Bogotá, Colombia).

            Carmen Balañá,

            Departamento de Oncología Médica, Sección Neuro-oncología, Hospital Germans Trias i Pujol, Instituto Catalán de Oncología (ICO) (Barcelona, España).

            Alejandro Blanco,

            Departamento de Radioterapia, Hospital México (San José de Costa Rica, Costa Rica).

            El dogma sobre la génesis de las células es un evento insignificante en el cerebro de los mamíferos adultos, que ha influenciado nuestra percepción y la comprensión del origen y desarrollo de los tumores del sistema nervioso central. El descubrimiento de que las neuronas y la neuroglia se generan a lo largo de la vida a partir de células progenitoras proporciona nuevas posibilidades para definir la clonalidad y el comportamiento de las neoplasias cerebrales. La hipótesis detrás de este hallazgo está soportada por las modificaciones celulares y los mecanismos genéticos que controlan la neurogénesis normal y tumoral, lo que permite la identificación de nuevas estrategias terapéuticas.

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